Cancer - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols XRCC6 and SDHC	Name 1 X-ray repair cross complementing 6	Name2 succinate dehydrogenase complex subunit C	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	Drugs 1	Drugs 2 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1	Diseases 1	Diseases 2
Novel Novel	Symbols XRCC6 and RNF146	Name 1 X-ray repair cross complementing 6	Name2 ring finger protein 146	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols XRCC6 and GZMB	Name 1 X-ray repair cross complementing 6	Name2 granzyme B	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols XRCC6 and ZNF512B	Name 1 X-ray repair cross complementing 6	Name2 zinc finger protein 512B	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 RHOV GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MITF and TFEB	Name 1 melanocyte inducing transcription factor	Name2 transcription factor EB	Pathway 1 SUMOylation of transcription factors Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Drugs 1	Drugs 2	Diseases 1 Malignant melanoma Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS)	Diseases 2
Novel Novel	Symbols YBX1 and JAM2	Name 1 Y-box binding protein 1	Name2 junctional adhesion molecule 2	Pathway 1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3	Pathway 2 Cell surface interactions at the vascular wall Integrin cell surface interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MC4R and ATRNL1	Name 1 melanocortin 4 receptor	Name2 attractin like 1	Pathway 1 Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Bremelanotide Setmelanotide	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCM7 and MBIP	Name 1 minichromosome maintenance complex component 7	Name2 MAP3K12 binding inhibitory protein 1	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCM7 and MCM8	Name 1 minichromosome maintenance complex component 7	Name2 minichromosome maintenance 8 homologous recombination repair factor	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCM7 and C8orf34	Name 1 minichromosome maintenance complex component 7	Name2 chromosome 8 open reading frame 34	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCM7 and CEP68	Name 1 minichromosome maintenance complex component 7	Name2 centrosomal protein 68	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols MCM7 and RNF181	Name 1 minichromosome maintenance complex component 7	Name2 ring finger protein 181	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 E3 ubiquitin ligases ubiquitinate target proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and IGFBP5	Name 1 four and a half LIM domains 2	Name2 insulin like growth factor binding protein 5	Pathway 1 PPARA activates gene expression	Pathway 2 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and KIAA1217	Name 1 four and a half LIM domains 2	Name2 KIAA1217	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and GLYR1	Name 1 four and a half LIM domains 2	Name2 glyoxylate reductase 1 homolog	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and BARX2	Name 1 four and a half LIM domains 2	Name2 BARX homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and TOX3	Name 1 four and a half LIM domains 2	Name2 TOX high mobility group box family member 3	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and A1CF	Name 1 four and a half LIM domains 2	Name2 APOBEC1 complementation factor	Pathway 1 PPARA activates gene expression	Pathway 2 mRNA Editing: C to U Conversion Formation of the Editosome	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and PKNOX2	Name 1 four and a half LIM domains 2	Name2 PBX/knotted 1 homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols FHL2 and IL16	Name 1 four and a half LIM domains 2	Name2 interleukin 16	Pathway 1 PPARA activates gene expression	Pathway 2 Other interleukin signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols XRCC6 and SDHC	Name 1 X-ray repair cross complementing 6	Name2 succinate dehydrogenase complex subunit C	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle	Drugs 1	Drugs 2 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1	Diseases 1	Diseases 2
Novel	Symbols XRCC6 and RNF146	Name 1 X-ray repair cross complementing 6	Name2 ring finger protein 146	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols XRCC6 and GZMB	Name 1 X-ray repair cross complementing 6	Name2 granzyme B	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols XRCC6 and ZNF512B	Name 1 X-ray repair cross complementing 6	Name2 zinc finger protein 512B	Pathway 1 2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Pathway 2 RHOV GTPase cycle	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MITF and TFEB	Name 1 melanocyte inducing transcription factor	Name2 transcription factor EB	Pathway 1 SUMOylation of transcription factors Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2 Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Drugs 1	Drugs 2	Diseases 1 Malignant melanoma Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS)	Diseases 2
Novel	Symbols YBX1 and JAM2	Name 1 Y-box binding protein 1	Name2 junctional adhesion molecule 2	Pathway 1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3	Pathway 2 Cell surface interactions at the vascular wall Integrin cell surface interactions	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MC4R and ATRNL1	Name 1 melanocortin 4 receptor	Name2 attractin like 1	Pathway 1 Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Pathway 2	Drugs 1 Bremelanotide Setmelanotide	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCM7 and MBIP	Name 1 minichromosome maintenance complex component 7	Name2 MAP3K12 binding inhibitory protein 1	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCM7 and MCM8	Name 1 minichromosome maintenance complex component 7	Name2 minichromosome maintenance 8 homologous recombination repair factor	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCM7 and C8orf34	Name 1 minichromosome maintenance complex component 7	Name2 chromosome 8 open reading frame 34	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCM7 and CEP68	Name 1 minichromosome maintenance complex component 7	Name2 centrosomal protein 68	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols MCM7 and RNF181	Name 1 minichromosome maintenance complex component 7	Name2 ring finger protein 181	Pathway 1 Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Pathway 2 E3 ubiquitin ligases ubiquitinate target proteins	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and IGFBP5	Name 1 four and a half LIM domains 2	Name2 insulin like growth factor binding protein 5	Pathway 1 PPARA activates gene expression	Pathway 2 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and KIAA1217	Name 1 four and a half LIM domains 2	Name2 KIAA1217	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and GLYR1	Name 1 four and a half LIM domains 2	Name2 glyoxylate reductase 1 homolog	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and BARX2	Name 1 four and a half LIM domains 2	Name2 BARX homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and TOX3	Name 1 four and a half LIM domains 2	Name2 TOX high mobility group box family member 3	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and A1CF	Name 1 four and a half LIM domains 2	Name2 APOBEC1 complementation factor	Pathway 1 PPARA activates gene expression	Pathway 2 mRNA Editing: C to U Conversion Formation of the Editosome	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and PKNOX2	Name 1 four and a half LIM domains 2	Name2 PBX/knotted 1 homeobox 2	Pathway 1 PPARA activates gene expression	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols FHL2 and IL16	Name 1 four and a half LIM domains 2	Name2 interleukin 16	Pathway 1 PPARA activates gene expression	Pathway 2 Other interleukin signaling	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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