Diabetes - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols YY1 and FOXP2	Name 1 YY1 transcription factor	Name2 forkhead box P2	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression	Pathway 2 Positive Regulation of CDH1 Gene Transcription	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Speech-language disorder 1 (SPCH1)
Novel Novel	Symbols LBR and PRM1	Name 1 lamin B receptor	Name2 protamine 1	Pathway 1 Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity	Pathway 2 Replacement of protamines by nucleosomes in the male pronucleus	Drugs 1	Drugs 2	Diseases 1 HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	Diseases 2
Novel Novel	Symbols KLC1 and ODF1	Name 1 kinesin light chain 1	Name2 outer dense fiber of sperm tails 1	Pathway 1 MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ERBB4 and PTPDC1	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 protein tyrosine phosphatase domain containing 1	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ERBB4 and FAM241B	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 family with sequence similarity 241 member B	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ERBB4 and NRG4	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 neuregulin 4	Pathway 1	Pathway 2 Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ERBB4 and NRG3	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 neuregulin 3	Pathway 1	Pathway 2 Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BAX and FBXL20	Name 1 BCL2 associated X, apoptosis regulator	Name2 F-box and leucine rich repeat protein 20	Pathway 1 Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor	Pathway 2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 TAK-901	Drugs 2	Diseases 1 Colorectal cancer	Diseases 2
Novel Novel	Symbols ABCA1 and FADD	Name 1 ATP binding cassette subfamily A member 1	Name2 Fas associated via death domain	Pathway 1 PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pathway 2 Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis	Drugs 1 ATP Glyburide Probucol	Drugs 2	Diseases 1 Tangier disease Hypoalphalipoproteinemia	Diseases 2
Novel Novel	Symbols ABCA1 and LMO7	Name 1 ATP binding cassette subfamily A member 1	Name2 LIM domain 7	Pathway 1 PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pathway 2 Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 ATP Glyburide Probucol	Drugs 2	Diseases 1 Tangier disease Hypoalphalipoproteinemia	Diseases 2
Novel Novel	Symbols PTPN12 and RBM19	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 RNA binding motif protein 19	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PTPN12 and LMTK2	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 lemur tyrosine kinase 2	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PDE4D and AKAP6	Name 1 phosphodiesterase 4D	Name2 A-kinase anchoring protein 6	Pathway 1 DARPP-32 events G alpha (s) signalling events	Pathway 2	Drugs 1 Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Papaverine Amrinone Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AIRE and CREBBP	Name 1 autoimmune regulator	Name2 CREB binding lysine acetyltransferase	Pathway 1	Pathway 2 Regulation of gene expression by Hypoxia-inducible Factor BMAL1:CLOCK,NPAS2 activates circadian expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1 Heme signaling Nuclear events mediated by NFE2L2 NPAS4 regulates expression of target genes Formation of paraxial mesoderm NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Zygotic genome activation (ZGA) Evasion by RSV of host interferon responses MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Drugs 1	Drugs 2 Colforsin 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE	Diseases 1 Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Diseases 2 Rubinstein-Taybi syndrome
Novel Novel	Symbols AP1B1 and AGR3	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 anterior gradient 3, protein disulphide isomerase family member	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols AP1B1 and ARF5	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 ARF GTPase 5	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CDKN2A and HLA-DOB	Name 1 cyclin dependent kinase inhibitor 2A	Name2 major histocompatibility complex, class II, DO beta	Pathway 1 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Nuclear events mediated by NFE2L2	Pathway 2 MHC class II antigen presentation	Drugs 1	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Non-small cell lung cancer Malignant islet cell carcinoma Adult T-cell leukemia Esophageal cancer Glioma Pancreatic cancer Nasopharyngeal cancer Hepatocellular carcinoma Squamous cell carcinoma Penile cancer Oral cancer Malignant melanoma Burkitt lymphoma Gallbladder cancer Bladder cancer Laryngeal cancer Cholangiocarcinoma Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus	Diseases 2
Novel Novel	Symbols TLE5 and SIX3	Name 1 TLE family member 5, transcriptional modulator	Name2 SIX homeobox 3	Pathway 1 Repression of WNT target genes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols TLE5 and BCL6	Name 1 TLE family member 5, transcriptional modulator	Name2 BCL6 transcription repressor	Pathway 1 Repression of WNT target genes	Pathway 2 Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Hairy-cell leukemia
Novel Novel	Symbols TLE5 and CRACR2A	Name 1 TLE family member 5, transcriptional modulator	Name2 calcium release activated channel regulator 2A	Pathway 1 Repression of WNT target genes	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols YY1 and FOXP2	Name 1 YY1 transcription factor	Name2 forkhead box P2	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression	Pathway 2 Positive Regulation of CDH1 Gene Transcription	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Speech-language disorder 1 (SPCH1)
Novel	Symbols LBR and PRM1	Name 1 lamin B receptor	Name2 protamine 1	Pathway 1 Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity	Pathway 2 Replacement of protamines by nucleosomes in the male pronucleus	Drugs 1	Drugs 2	Diseases 1 HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	Diseases 2
Novel	Symbols KLC1 and ODF1	Name 1 kinesin light chain 1	Name2 outer dense fiber of sperm tails 1	Pathway 1 MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ERBB4 and PTPDC1	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 protein tyrosine phosphatase domain containing 1	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ERBB4 and FAM241B	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 family with sequence similarity 241 member B	Pathway 1	Pathway 2	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ERBB4 and NRG4	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 neuregulin 4	Pathway 1	Pathway 2 Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ERBB4 and NRG3	Name 1 erb-b2 receptor tyrosine kinase 4	Name2 neuregulin 3	Pathway 1	Pathway 2 Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Drugs 1 Afatinib Fostamatinib Brigatinib Zanubrutinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BAX and FBXL20	Name 1 BCL2 associated X, apoptosis regulator	Name2 F-box and leucine rich repeat protein 20	Pathway 1 Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor	Pathway 2 Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 TAK-901	Drugs 2	Diseases 1 Colorectal cancer	Diseases 2
Novel	Symbols ABCA1 and FADD	Name 1 ATP binding cassette subfamily A member 1	Name2 Fas associated via death domain	Pathway 1 PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pathway 2 Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis	Drugs 1 ATP Glyburide Probucol	Drugs 2	Diseases 1 Tangier disease Hypoalphalipoproteinemia	Diseases 2
Novel	Symbols ABCA1 and LMO7	Name 1 ATP binding cassette subfamily A member 1	Name2 LIM domain 7	Pathway 1 PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pathway 2 Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 ATP Glyburide Probucol	Drugs 2	Diseases 1 Tangier disease Hypoalphalipoproteinemia	Diseases 2
Novel	Symbols PTPN12 and RBM19	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 RNA binding motif protein 19	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PTPN12 and LMTK2	Name 1 protein tyrosine phosphatase non-receptor type 12	Name2 lemur tyrosine kinase 2	Pathway 1 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	Pathway 2	Drugs 1 Tiludronic acid	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PDE4D and AKAP6	Name 1 phosphodiesterase 4D	Name2 A-kinase anchoring protein 6	Pathway 1 DARPP-32 events G alpha (s) signalling events	Pathway 2	Drugs 1 Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Papaverine Amrinone Roflumilast Piclamilast Rolipram Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AIRE and CREBBP	Name 1 autoimmune regulator	Name2 CREB binding lysine acetyltransferase	Pathway 1	Pathway 2 Regulation of gene expression by Hypoxia-inducible Factor BMAL1:CLOCK,NPAS2 activates circadian expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1 Heme signaling Nuclear events mediated by NFE2L2 NPAS4 regulates expression of target genes Formation of paraxial mesoderm NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Zygotic genome activation (ZGA) Evasion by RSV of host interferon responses MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Drugs 1	Drugs 2 Colforsin 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE	Diseases 1 Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Diseases 2 Rubinstein-Taybi syndrome
Novel	Symbols AP1B1 and AGR3	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 anterior gradient 3, protein disulphide isomerase family member	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols AP1B1 and ARF5	Name 1 adaptor related protein complex 1 subunit beta 1	Name2 ARF GTPase 5	Pathway 1 Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Pathway 2 COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CDKN2A and HLA-DOB	Name 1 cyclin dependent kinase inhibitor 2A	Name2 major histocompatibility complex, class II, DO beta	Pathway 1 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Nuclear events mediated by NFE2L2	Pathway 2 MHC class II antigen presentation	Drugs 1	Drugs 2	Diseases 1 Chronic myeloid leukemia (CML) Non-small cell lung cancer Malignant islet cell carcinoma Adult T-cell leukemia Esophageal cancer Glioma Pancreatic cancer Nasopharyngeal cancer Hepatocellular carcinoma Squamous cell carcinoma Penile cancer Oral cancer Malignant melanoma Burkitt lymphoma Gallbladder cancer Bladder cancer Laryngeal cancer Cholangiocarcinoma Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus	Diseases 2
Novel	Symbols TLE5 and SIX3	Name 1 TLE family member 5, transcriptional modulator	Name2 SIX homeobox 3	Pathway 1 Repression of WNT target genes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols TLE5 and BCL6	Name 1 TLE family member 5, transcriptional modulator	Name2 BCL6 transcription repressor	Pathway 1 Repression of WNT target genes	Pathway 2 Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Hairy-cell leukemia
Novel	Symbols TLE5 and CRACR2A	Name 1 TLE family member 5, transcriptional modulator	Name2 calcium release activated channel regulator 2A	Pathway 1 Repression of WNT target genes	Pathway 2 Neutrophil degranulation	Drugs 1	Drugs 2	Diseases 1	Diseases 2

Page 34 out of 58 pages

Search Results : Diabetes