CTNNA3 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
OIP5	Opa interacting protein 5	Deposition of new CENPA-containing nucleosomes at the centromere
ORC2	origin recognition complex subunit 2	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
PAX6	paired box 6	Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of the anterior neural plate		Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON) Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
PLAGL2	PLAG1 like zinc finger 2
PNMA1	PNMA family member 1
PNMA5	PNMA family member 5
POU6F2	POU class 6 homeobox 2
PPARA	peroxisome proliferator activated receptor alpha	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Cytoprotection by HMOX1 Heme signaling Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
PRR5	proline rich 5	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
REL	REL proto-oncogene, NF-kB subunit	Activation of NF-kappaB in B cells		Hodgkin lymphoma
RIPPLY1	ripply transcriptional repressor 1
RPS6KA5	ribosomal protein S6 kinase A5	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
SERTAD2	SERTA domain containing 2
SPATS1	spermatogenesis associated serine rich 1
STMN2	stathmin 2	RND1 GTPase cycle
TASOR2	transcription activation suppressor family member 2
TLX3	T cell leukemia homeobox 3			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
TNNI1	troponin I1, slow skeletal type	Striated Muscle Contraction
TNNI2	troponin I2, fast skeletal type	Striated Muscle Contraction		Distal arthrogryposis (DA)
TRIM54	tripartite motif containing 54

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