|
OIP5
|
Opa interacting protein 5 |
- Deposition of new CENPA-containing nucleosomes at the centromere
|
|
|
|
ORC2
|
origin recognition complex subunit 2 |
- E2F-enabled inhibition of pre-replication complex formation
- Activation of ATR in response to replication stress
- Assembly of the ORC complex at the origin of replication
- CDC6 association with the ORC:origin complex
- Assembly of the pre-replicative complex
- Orc1 removal from chromatin
- Activation of the pre-replicative complex
|
|
|
|
PAX6
|
paired box 6 |
- Regulation of gene expression in beta cells
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Formation of the anterior neural plate
|
|
- Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
- Aniridia
- Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
|
|
PLAGL2
|
PLAG1 like zinc finger 2 |
|
|
|
|
PNMA1
|
PNMA family member 1 |
|
|
|
|
PNMA5
|
PNMA family member 5 |
|
|
|
|
POU6F2
|
POU class 6 homeobox 2 |
|
|
|
|
PPARA
|
peroxisome proliferator activated receptor alpha |
- BMAL1:CLOCK,NPAS2 activates circadian expression
- PPARA activates gene expression
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by PPARalpha
- SUMOylation of intracellular receptors
- Cytoprotection by HMOX1
- Heme signaling
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
- Expression of BMAL (ARNTL), CLOCK, and NPAS2
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
|
- alpha-Linolenic acid
- Icosapent
- Troglitazone
- Valproic acid
- Indomethacin
- Rosiglitazone
- Fenoprofen
- Clofibrate
- Fenofibrate
- Ibuprofen
- Amiodarone
- Gemfibrozil
- Bezafibrate
- Prasterone
- N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
- Flufenamic acid
- Resveratrol
- Phthalic Acid
- Lauric acid
- Stearic acid
- Doconexent
- Palmitic Acid
- Oleic Acid
- Caprylic acid
- Arachidonic Acid
- Reglitazar
- Elafibranor
- Cardarine
- Muraglitazar
- Ertiprotafib
- Ragaglitazar
- Tesaglitazar
- GW-590735
- Indeglitazar
- Myristic acid
- Aleglitazar
- Clinofibrate
- Ciprofibrate
- Dexibuprofen
- Soybean oil
- Omega-3 fatty acids
- Myrrh
- Isoflavone
- Leukotriene B4
- Fenofibric acid
- Fish oil
|
|
|
PRR5
|
proline rich 5 |
- PIP3 activates AKT signaling
- CD28 dependent PI3K/Akt signaling
- VEGFR2 mediated vascular permeability
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of TP53 Degradation
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
|
|
|
|
REL
|
REL proto-oncogene, NF-kB subunit |
- Activation of NF-kappaB in B cells
|
|
|
|
RIPPLY1
|
ripply transcriptional repressor 1 |
|
|
|
|
RPS6KA5
|
ribosomal protein S6 kinase A5 |
- ERK/MAPK targets
- CREB phosphorylation
- NCAM signaling for neurite out-growth
- Recycling pathway of L1
- CD209 (DC-SIGN) signaling
|
|
|
|
SERTAD2
|
SERTA domain containing 2 |
|
|
|
|
SPATS1
|
spermatogenesis associated serine rich 1 |
|
|
|
|
STMN2
|
stathmin 2 |
|
|
|
|
TASOR2
|
transcription activation suppressor family member 2 |
|
|
|
|
TLX3
|
T cell leukemia homeobox 3 |
|
|
- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
|
|
TNNI1
|
troponin I1, slow skeletal type |
- Striated Muscle Contraction
|
|
|
|
TNNI2
|
troponin I2, fast skeletal type |
- Striated Muscle Contraction
|
|
- Distal arthrogryposis (DA)
|
|
TRIM54
|
tripartite motif containing 54 |
|
|
|