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DDX1
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DEAD-box helicase 1 |
- tRNA processing in the nucleus
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DYRK2
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dual specificity tyrosine phosphorylation regulated kinase 2 |
- Regulation of TP53 Activity through Phosphorylation
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E2F1
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E2F transcription factor 1 |
- Activation of NOXA and translocation to mitochondria
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- G2 Phase
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by E2F6
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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E4F1
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E4F transcription factor 1 |
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EEF1E1
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eukaryotic translation elongation factor 1 epsilon 1 |
- Selenoamino acid metabolism
- Cytosolic tRNA aminoacylation
- Transcriptional and post-translational regulation of MITF-M expression and activity
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EIF3E
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eukaryotic translation initiation factor 3 subunit E |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
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EIF4EBP1
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eukaryotic translation initiation factor 4E binding protein 1 |
- mTORC1-mediated signalling
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
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EP400
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E1A binding protein p400 |
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
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EPHA5
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EPH receptor A5 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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ERRFI1
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ERBB receptor feedback inhibitor 1 |
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ESRRG
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estrogen related receptor gamma |
- Nuclear Receptor transcription pathway
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- Troglitazone
- Diethylstilbestrol
- Tamoxifen
- Cholic Acid
- Afimoxifene
- 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
- p-Cumylphenol
- Bisphenol A
- Bisphenol Z
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate
- Estradiol dienanthate
- Estradiol valerate
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EXO1
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exonuclease 1 |
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
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FANCD2
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FA complementation group D2 |
- Fanconi Anemia Pathway
- TP53 Regulates Transcription of DNA Repair Genes
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FECH
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ferrochelatase |
- Heme biosynthesis
- Mitochondrial protein degradation
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- Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
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FUS
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FUS RNA binding protein |
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
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- Myxoid liposarcoma
- Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
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H1-2
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H1.2 linker histone, cluster member |
- Apoptosis induced DNA fragmentation
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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H2AX
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H2A.X variant histone |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Pre-NOTCH Transcription and Translation
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- PRC2 methylates histones and DNA
- Condensation of Prophase Chromosomes
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- RMTs methylate histone arginines
- SIRT1 negatively regulates rRNA expression
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- NoRC negatively regulates rRNA expression
- NoRC negatively regulates rRNA expression
- B-WICH complex positively regulates rRNA expression
- DNA methylation
- Transcriptional regulation by small RNAs
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Deposition of new CENPA-containing nucleosomes at the centromere
- Assembly of the ORC complex at the origin of replication
- G2/M DNA damage checkpoint
- RNA Polymerase I Promoter Opening
- RNA Polymerase I Promoter Escape
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Estrogen-dependent gene expression
- Meiotic recombination
- Transcriptional regulation of granulopoiesis
- Inhibition of DNA recombination at telomere
- Defective pyroptosis
- Negative Regulation of CDH1 Gene Transcription
- Amyloid fiber formation
- Chromatin modifications during the maternal to zygotic transition (MZT)
- Replacement of protamines by nucleosomes in the male pronucleus
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- Regulation of endogenous retroelements by KRAB-ZFP proteins
- Regulation of endogenous retroelements by KRAB-ZFP proteins
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
- Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Regulation of PD-L1(CD274) transcription
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HIF1A
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hypoxia inducible factor 1 subunit alpha |
- Regulation of gene expression by Hypoxia-inducible Factor
- Cellular response to hypoxia
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- NOTCH1 Intracellular Domain Regulates Transcription
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- PTK6 Expression
- PTK6 promotes HIF1A stabilization
- Neddylation
- STAT3 nuclear events downstream of ALK signaling
- Regulation of PD-L1(CD274) transcription
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- Carvedilol
- Hydralazine
- 2-Methoxyestradiol
- ENMD-1198
- PX-478
- FG-2216
- Vadadustat
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HMGA1
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high mobility group AT-hook 1 |
- Integration of provirus
- 2-LTR circle formation
- Integration of viral DNA into host genomic DNA
- Autointegration results in viral DNA circles
- APOBEC3G mediated resistance to HIV-1 infection
- Vpr-mediated nuclear import of PICs
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
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HSPA8
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heat shock protein family A (Hsp70) member 8 |
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
- Attenuation phase
- HSF1-dependent transactivation
- Lysosome Vesicle Biogenesis
- Golgi Associated Vesicle Biogenesis
- CHL1 interactions
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Interleukin-4 and Interleukin-13 signaling
- Neutrophil degranulation
- mRNA Splicing - Major Pathway
- Clathrin-mediated endocytosis
- Protein methylation
- GABA synthesis, release, reuptake and degradation
- Lipophagy
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Respiratory syncytial virus genome transcription
- PKR-mediated signaling
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- Dasatinib
- (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
- Copper
- Artenimol
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