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BEX1
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brain expressed X-linked 1 |
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BFAR
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bifunctional apoptosis regulator |
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BID
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BH3 interacting domain death agonist |
- Activation of BAD and translocation to mitochondria
- Activation and oligomerization of BAK protein
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Activation, translocation and oligomerization of BAX
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- Activation, myristolyation of BID and translocation to mitochondria
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BIRC6
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baculoviral IAP repeat containing 6 |
- ALK mutants bind TKIs
- Signaling by ALK fusions and activated point mutants
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BLID
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BH3-like motif containing, cell death inducer |
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BRD1
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bromodomain containing 1 |
- HATs acetylate histones
- Regulation of TP53 Activity through Acetylation
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CASC3
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CASC3 exon junction complex subunit |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA Splicing - Major Pathway
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
- Regulation of expression of SLITs and ROBOs
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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CASP1
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caspase 1 |
- NOD1/2 Signaling Pathway
- Interleukin-1 processing
- Pyroptosis
- TP53 Regulates Transcription of Caspase Activators and Caspases
- The NLRP3 inflammasome
- The AIM2 inflammasome
- The IPAF inflammasome
- Interleukin-37 signaling
- Purinergic signaling in leishmaniasis infection
- SARS-CoV-1 activates/modulates innate immune responses
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- Acetylsalicylic acid
- Minocycline
- Pralnacasan
- LAX-101
- Emricasan
- VX-765
- 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
- Z-Val-Ala-Asp fluoromethyl ketone
- 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
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CASP10
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caspase 10 |
- TP53 Regulates Transcription of Caspase Activators and Caspases
- FasL/ CD95L signaling
- TRAIL signaling
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
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- Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
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CASP14
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caspase 14 |
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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CASP2
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caspase 2 |
- NOD1/2 Signaling Pathway
- NADE modulates death signalling
- TP53 Regulates Transcription of Caspase Activators and Caspases
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CASP3
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caspase 3 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Apoptosis induced DNA fragmentation
- Degradation of the extracellular matrix
- Signaling by Hippo
- NADE modulates death signalling
- Stimulation of the cell death response by PAK-2p34
- Caspase-mediated cleavage of cytoskeletal proteins
- Apoptotic cleavage of cell adhesion proteins
- Caspase activation via Dependence Receptors in the absence of ligand
- Caspase activation via Dependence Receptors in the absence of ligand
- Other interleukin signaling
- Pyroptosis
- CASP4-mediated substrate cleavage
- CASP5-mediated substrate cleavage
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- Pamidronic acid
- Acetylsalicylic acid
- Minocycline
- 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
- Emricasan
- Incadronic acid
- 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
- methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
- 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
- [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
- 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
- (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
- (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
- N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
- Tributyrin
- Oleandrin
- PAC-1
- Glycyrrhizic acid
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CASP4
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caspase 4 |
- NOD1/2 Signaling Pathway
- Pyroptosis
- CASP4 inflammasome assembly
- Microbial factors inhibit CASP4 activity
- CASP4-mediated substrate cleavage
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CASP6
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caspase 6 |
- Apoptotic cleavage of cellular proteins
- Caspase-mediated cleavage of cytoskeletal proteins
- Breakdown of the nuclear lamina
- TP53 Regulates Transcription of Caspase Activators and Caspases
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CASP7
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caspase 7 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Caspase-mediated cleavage of cytoskeletal proteins
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- Fica
- Emricasan
- Incadronic acid
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CASP8AP2
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caspase 8 associated protein 2 |
- SUMOylation of transcription cofactors
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CASP9
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caspase 9 |
- Formation of apoptosome
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- NOD1/2 Signaling Pathway
- AKT phosphorylates targets in the cytosol
- Caspase activation via Dependence Receptors in the absence of ligand
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of the apoptosome activity
- Regulation of the apoptosome activity
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CCNL1
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cyclin L1 |
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CDH1
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cadherin 1 |
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Integrin cell surface interactions
- Apoptotic cleavage of cell adhesion proteins
- Adherens junctions interactions
- RHO GTPases activate IQGAPs
- InlA-mediated entry of Listeria monocytogenes into host cells
- Regulation of CDH1 Function
- Regulation of CDH1 mRNA translation by microRNAs
- Degradation of CDH1
- Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
- Formation of definitive endoderm
- Transcriptional and post-translational regulation of MITF-M expression and activity
- Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Myoepithelial Cells
- Developmental Lineage of Mammary Stem Cells
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- Penile cancer
- Breast cancer
- Gastric cancer
- Nasopharyngeal cancer
- Hepatocellular carcinoma
- Thyroid cancer
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CDH13
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cadherin 13 |
- Adherens junctions interactions
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