ORM1 and PIK3R3

Number of citations: 0 (PubMedID 18624398)
Data Source: BioGRID (two hybrid)

		ORM1	PIK3R3
Name		orosomucoid 1	phosphoinositide-3-kinase regulatory subunit 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle Tertiary Granule Lumen	Cytosol Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Protein Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Regulation Of Immune System Process Acute-phase Response Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production	Cell Migration Involved In Sprouting Angiogenesis Immune Response Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Anoikis
Pathways		Platelet degranulation Neutrophil degranulation	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Co-stimulation by ICOS
Drugs		Amsacrine Lidocaine Progesterone Chlorpromazine Dipyridamole Thalidomide	SF1126
GWAS		End-stage coagulation ( 23381943 ) Thrombin generation potential phenotypes ( 24357727 ) Tourette syndrome ( 22889924 )	Body mass index ( 26426971 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 ) Lymphocyte percentage of white cells ( 32888494 ) Metabolite levels ( 23823483 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Red cell distribution width ( 32888494 ) Serum metabolite levels ( 33031748 ) Sodium levels ( 29403010 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 27863252 )
Interacting Genes		9 interacting genes: ALB BLVRB CCR5 GLUD1 GSDMB PIK3R3 SERPINE1 TMEM37 TP63	122 interacting genes: ABCB6 ABL2 AMBP ANKS1A ANTKMT AR ARID4B AUNIP AXL BLK BLZF1 BRK1 BTK C3orf36 CAMK1 CCDC14 CCDC196 CCDC33 CCDC89 CEP126 CEP19 CHRDL2 CIMIP2B CLNK CRBN CRK DARS1 DCAF8 DISC1 DRAP1 DSN1 E2F6 EGFR ENKD1 ERBB2 ERBB3 ERBB4 ESR1 FBN3 FER FGB FNDC8 FOXO1 FSD2 FYN GAB1 GC GRB2 HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 ITGB3BP KARS1 KHDRBS1 KIAA0408 KIT KLC2 KLF15 KMT2B L3MBTL3 LAP3 LNX2 LUC7L2 MBIP MECOM MET MICAL1 MTF2 NAB2 NCK1 NEBL NEDD9 ORM1 PACRGL PBX4 PCDHB5 PDGFRB PELO PIK3CA PLAAT4 PLB1 PLEKHF2 PPARA PRKAR1B PSME1 PTK2 QARS1 RB1 RING1 RUSC1 SERF1A SERTAD2 SPATA32 SPMIP6 SRC SSBP4 STAT3 STAT5B TASOR2 TEC TERF2 TNK2 TNNC2 TNNI1 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 YES1 YPEL3 ZBTB18 ZMAT1 ZNF281 ZNF451 ZNF620
Entrez ID		5004	8503
HPRD ID		00724	05831
Ensembl ID		ENSG00000229314	ENSG00000117461
Uniprot IDs		P02763	B4DXM8 Q8N381 Q92569
PDB IDs		3KQ0	Not available
GO Terms Enriched among Interactors		Platelet Alpha Granule Lumen Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Biliverdin Reductase [NAD(P)H] Activity Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity Insulin Receptor Signaling Pathway FMN Reductase (NADH) Activity Chemokine (C-C Motif) Ligand 5 Binding Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Defense Response To Gram-negative Bacterium Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Cytotoxic T Cell Pyroptotic Cell Death Odontogenesis Peptidyl-cysteine S-nitrosylase Activity Negative Regulation Of Integrin-mediated Signaling Pathway Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Regulation Of Smooth Muscle Cell-matrix Adhesion Peptidase Inhibitor Complex Prostatic Bud Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Negative Regulation Of Mitochondrial Depolarization Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Calcium Ion Transmembrane Transport Negative Regulation Of Macrophage Apoptotic Process L-leucine Binding Glutamate Biosynthetic Process L-glutamate Catabolic Process Positive Regulation Of Odontoblast Differentiation Dentinogenesis Negative Regulation Of Vascular Wound Healing Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Plasminogen Activation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB Signaling Pathway Kinase Activity Phosphorylation Negative Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Phosphorylation Ephrin Receptor Binding Positive Regulation Of Phosphate Metabolic Process Ephrin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Binding Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Response To Peptide Hormone SH2 Domain Binding Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Programmed Cell Death ATP Binding Positive Regulation Of Cell Population Proliferation Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Regulation Of Phosphorus Metabolic Process Cell Population Proliferation Insulin Receptor Complex Transferase Activity Positive Regulation Of Cellular Component Organization Receptor Complex Signaling Adaptor Activity Insulin Receptor Substrate Binding Regulation Of Signal Transduction Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway