SPCS2

Name	signal peptidase complex subunit 2
Structure
Interactors	6 interactors: ATP13A2 CLN8 EGFR FNDC3B STMN3 TEFM
GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding
	Biological Process	Signal Peptide Processing Protein Targeting To ER
Pathways	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
GWAS	No GWAS studies recorded
Entrez ID	9789
HPRD ID	15435
Ensembl ID	ENSG00000118363
Uniprot IDs	Q15005
PDB IDs	7P2P 7P2Q
GO Terms Enriched among Interactors ?	Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Protein Metabolic Process Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Transcription Elongation By Mitochondrial RNA Polymerase Positive Regulation Of Mitochondrial Transcription Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Vacuole Organization Lipid Homeostasis Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Negative Regulation Of Rac Protein Signal Transduction Retinal Cell Apoptotic Process Polyamine Transmembrane Transport ERBB2-EGFR Signaling Pathway Ceramide Binding Regulation Of Cellular Component Size Regulation Of Neuron Apoptotic Process Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Transcription Elongation Factor Activity Crossover Junction DNA Endonuclease Activity Learning Or Memory Salivary Gland Morphogenesis Neurofilament Cytoskeleton Organization L-glutamate Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Mitochondrial DNA Replication Regulation Of Mitochondrial Transcription