SETD1A

Name	SET domain containing 1A, histone lysine methyltransferase
Structure
Novel Interactors	2 novel interactors: BCKDK TAOK2
Interactors	5 interactors: DPY30 EP300 H3C1 H3C14 LBP
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Beta-catenin Binding Methyltransferase Activity Transferase Activity Histone H3K4 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Brain Development Methylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization
Pathways	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes
GWAS	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Parkinson's disease ( 31660654 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Red blood cell count ( 32888494 )
Entrez ID	9739
HPRD ID	13795
Ensembl ID	ENSG00000099381
Uniprot IDs	O15047
PDB IDs	3S8S 3UVN 4EWR 8ILY
GO Terms Enriched among Interactors ?	Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Tau Protein Binding Chromatin Organization Epigenetic Regulation Of Gene Expression Peptidyl-lysine Propionylation Swimming Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Histone Crotonyltransferase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Structural Constituent Of Chromatin Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Regulation Of Glucose Metabolic Process Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Nucleosome Assembly N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Nucleosome Nucleosome Organization Basal Dendrite Morphogenesis Basal Dendrite Arborization Negative Regulation Of Protein Oligomerization Catalytic Activity, Acting On A Protein Chromosome Isoleucine Metabolic Process L-isoleucine Catabolic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity L-valine Catabolic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Innate Immune Response-activating Signaling Pathway Lipoteichoic Acid Binding Protein-DNA Complex Assembly Valine Metabolic Process L-leucine Catabolic Process Positive Regulation Of TORC2 Signaling