SPHK1

Name	sphingosine kinase 1
Structure
Novel Interactors	1 novel interactors: KCTD17
Interactors	12 interactors: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cilium Endosome Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Synapse Presynapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Lipid Kinase Activity DNA Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphingosine Kinase Activity Kinase Activity Acetyltransferase Activity Transferase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding
	Biological Process	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Acetylation Lipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Regulation Of Amide Metabolic Process Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Regulation Of Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Multicellular Organismal Process Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Sphingolipid Mediated Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion
Pathways	Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling PKR-mediated signaling
GWAS	High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Lymphocyte count ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) White blood cell count ( 32888494 )
Entrez ID	8877
HPRD ID	04768
Ensembl ID	ENSG00000176170
Uniprot IDs	Q53ZR5 Q9NYA1
PDB IDs	3VZB 3VZC 3VZD 4L02 4V24
GO Terms Enriched among Interactors ?	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Regulation Of Apoptotic Process Immune Response-activating Cell Surface Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Immune Response Regulation Of Programmed Cell Death Positive Regulation Of T Cell Activation Positive Regulation Of JUN Kinase Activity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway TORC2 Signaling Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Cell Activation Positive Regulation Of Intracellular Signal Transduction Response To Amino Acid Positive Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Serine/threonine Kinase Activity Transferase Activity Signal Transduction Protein-containing Complex Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Cell Projection Organization Positive Regulation Of Adaptive Immune Response Immune Response-activating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion