ASAP2

Name	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: RRM2
Interactors	14 interactors: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding
GWAS	Bipolar disorder ( 31043756 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronic widespread musculoskeletal pain ( 33331911 ) Pulse pressure ( 27841878 30578418 ) Urate levels ( 31578528 )
Entrez ID	8853
HPRD ID	04820
Ensembl ID	ENSG00000151693
Uniprot IDs	O43150
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Endocytosis Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Protein Polymerization Plasma Membrane Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Synaptic Vesicle Endocytosis Regulation Of Endocytosis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Presynaptic Endocytosis Cytosol Cell Cortex Lamellipodium Positive Regulation Of Cellular Component Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Organization Intracellular Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasm ERBB Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Apical Dendrite Negative Regulation Of Monoatomic Ion Transport GTPase Activity Cellular Localization Establishment Of Localization In Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transport Actin Cytoskeleton Organization Recycling Endosome GTP Binding