SOCS2

Name	suppressor of cytokine signaling 2
Structure
Novel Interactors	1 novel interactors: TBK1
Interactors	21 interactors: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TPD52 YES1
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development
Pathways	Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling
GWAS	Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340 ) Hepatic lipid content in extreme obesity ( 25246029 ) Hip circumference adjusted for BMI ( 34021172 ) Joint damage in rheumatoid arthritis ( 31596875 ) Pubertal anthropometrics ( 23449627 ) Type 2 diabetes ( 30054458 )
Entrez ID	8835
HPRD ID	05490
Ensembl ID	ENSG00000120833
Uniprot IDs	O14508
PDB IDs	2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS
GO Terms Enriched among Interactors ?	Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process