CRADD

Name	CARD and death domain containing adaptor protein
Structure
Interactors	22 interactors: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex
	Molecular Function	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding
	Biological Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways	TP53 Regulates Transcription of Caspase Activators and Caspases
GWAS	Alzheimer's disease (cognitive decline) ( 23535033 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 33713608 18391951 31217584 28552196 25282103 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Lung function (FVC) ( 30804560 30061609 ) Pulse pressure ( 27841878 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Reticulocyte count ( 32888494 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	8738
HPRD ID	04584
Ensembl ID	ENSG00000169372
Uniprot IDs	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs	2O71 2OF5 3CRD
GO Terms Enriched among Interactors ?	Positive Regulation Of Neuron Apoptotic Process Death Receptor Binding Endopeptidase Complex Extrinsic Apoptotic Signaling Pathway Signal Transduction Identical Protein Binding Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Regulation Of Macrophage Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Amyloid Fibril Formation Apoptotic Signaling Pathway Regulation Of Necroptotic Process Integrin Binding Actin Filament Uncapping Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Interleukin-9 Binding Interleukin-9 Receptor Activity Negative Regulation Of Eosinophil Extravasation Cellular Response To Thyrotropin-releasing Hormone Symbiont-containing Vacuole L-xylulose Reductase (NADPH) Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Supramolecular Fiber Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors