APOL1

Name	apolipoprotein L1
Structure
Novel Interactors	2 novel interactors: CACNA1I TRIM32
Interactors	2 interactors: APOA1 CDC23
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Blood Microparticle
	Molecular Function	Chloride Channel Activity Protein Binding Lipid Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Lipoprotein Metabolic Process Innate Immune Response Cytolysis By Host Of Symbiont Cells Chloride Transmembrane Transport
Pathways	Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS	Blood protein levels ( 30072576 ) Diabetic kidney disease ( 26305897 ) End-stage kidney disease ( 31178898 ) End-stage renal disease ( 29885931 ) Glomerulosclerosis ( 20668430 )
Entrez ID	8542
HPRD ID	04774
Ensembl ID	ENSG00000100342
Uniprot IDs	B1AH95 O14791 Q2KHQ6
PDB IDs	7L6K 7LF7 7LFA 7LFB 7LFD
GO Terms Enriched among Interactors ?	Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cellular Component Organization Apolipoprotein A-I Receptor Binding Peptidyl-methionine Modification Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Lipoprotein Biosynthetic Process Protein Oxidation Cholesterol Import High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux Regulation Of Organelle Organization Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Cytokine-mediated Signaling Pathway High-density Lipoprotein Particle Clearance Protein Polyubiquitination Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Sleep Protein Localization To Phagocytic Vesicle Actin Modification Striated Muscle Myosin Thick Filament Free Ubiquitin Chain Polymerization Cytosolic Ciliogenesis Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Adhesion Molecule Production Amyloid-beta Formation High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Positive Regulation Of Cell Cycle Tat Protein Binding Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Molecule Production Protein Modification Process Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Regulation Of Intestinal Absorption Positive Regulation Of Phospholipid Transport Glucocorticoid Metabolic Process High Voltage-gated Calcium Channel Activity High-density Lipoprotein Particle