ADAM12

Name	ADAM metallopeptidase domain 12
Structure	No pdb structure
Novel Interactors	2 novel interactors: DOCK1 TUBGCP2
Interactors	40 interactors: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways	Signaling by EGFR Invadopodia formation
GWAS	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Endometrial cancer ( 24096698 ) Extremely high intelligence ( 29731509 ) Heel bone mineral density ( 30598549 ) Intraocular pressure ( 30054594 ) Itch intensity from mosquito bite ( 28199695 ) Loneliness ( 27629369 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Mild influenza (H1N1) infection ( 26379185 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 26184070 ) Placental abruption ( 29884306 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Visceral fat ( 22589738 )
Entrez ID	8038
HPRD ID	04092
Ensembl ID	ENSG00000148848
Uniprot IDs	A8K6G4 O43184 Q5JRP2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Intermediate Filament Keratin Filament Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Developmental Process Fibronectin Binding Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Phosphotyrosine Residue Binding T Cell Costimulation Insulin-like Growth Factor II Binding Protein Binding Cytosol Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Epidermis Development Hair Cycle Negative Regulation Of Cell-substrate Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Keratinization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of MAPK Cascade Angiotensin-activated Signaling Pathway Actin Filament Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway