PNPLA3

Name	patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
Structure	No pdb structure
Novel Interactors	1 novel interactors: FLT3
Interactors	3 interactors: AKT2 LINC00839 SNX27
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Acylglycerol O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Response To Sucrose Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine
Pathways	Acyl chain remodeling of DAG and TAG
GWAS	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Alanine aminotransferase levels ( 34315874 33547301 33339817 31219225 30718733 ) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Alanine transaminase levels ( 29403010 ) Alcohol-related hepatocellular carcinoma ( 34902334 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 31219225 34315874 29403010 33547301 33339817 ) Cirrhosis ( 31815349 ) Cirrhosis (alcohol related) ( 26482880 32853455 ) Cirrhosis (multi-trait analysis) ( 33310085 ) Gout ( 33832965 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 27863252 ) Hematological and biochemical traits ( 20139978 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Hepatic lipid content in extreme obesity ( 25246029 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alanine transaminase) ( 33972514 22001757 ) Liver fat content (MRI proton density fat fraction measure) ( 32247823 ) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823 ) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 ) Mean corpuscular volume ( 32888494 29403010 ) Mean platelet volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 21909109 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600 ) Nonalcoholic fatty liver disease ( 29271184 21423719 29385134 24531328 22719876 34841290 32298765 31311600 ) Nonalcoholic steatohepatitis ( 32298765 ) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Percent liver fat ( 34128465 ) Platelet count ( 27863252 29403010 32888494 ) Plateletcrit ( 32888494 27863252 ) Red cell distribution width ( 32888494 28957414 27863252 ) Serum uric acid levels ( 30993211 ) Total cholesterol levels ( 30275531 33339817 31217584 ) Total triglycerides levels ( 26690388 ) Triacylglycerol 56:6 levels ( 31560688 ) Type 2 diabetes ( 29632382 30297969 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Urate levels ( 31578528 )
Entrez ID	80339
HPRD ID	12430
Ensembl ID	ENSG00000100344
Uniprot IDs	Q9NST1
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Early Endosome Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Peripheral Nervous System Myelin Maintenance Vascular Endothelial Growth Factor Receptor Activity Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Phosphatidylinositol 3-kinase Activator Activity Postsynaptic Recycling Endosome Establishment Of Natural Killer Cell Polarity Postsynaptic Early Endosome Cellular Response To Hormone Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Lymphoid Progenitor Cell Differentiation Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Response To Light Intensity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Glycogen Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Nuclear Glucocorticoid Receptor Binding WASH Complex Vascular Endothelial Growth Factor Signaling Pathway Protein Kinase Activity Localization Within Membrane Polysaccharide Biosynthetic Process Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Retromer Complex Molecular Function Activator Activity Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Protein Targeting To Membrane Regulation Of Synapse Maturation Regulation Of Glycogen Biosynthetic Process Liver Regeneration Regulation Of Protein Targeting To Membrane Kinase Activity