C6

Name	complement C6
Structure
Interactors	4 interactors: C5 F2 OGA SART3
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Protein Binding
	Biological Process	In Utero Embryonic Development Immune System Process Immune Response Complement Activation Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways	Terminal pathway of complement Regulation of Complement cascade
Diseases	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS	Refractive error ( 32231278 ) Response to fenofibrate (adiponectin levels) ( 23149075 )
Entrez ID	729
HPRD ID	01956
Ensembl ID	ENSG00000039537
Uniprot IDs	P13671
PDB IDs	3T5O 4A5W 4E0S 6H03 6H04 7NYC 7NYD 7Q6C 8B0F 8B0G 8B0H
GO Terms Enriched among Interactors ?	Receptor Ligand Activity Killing Of Cells Of Another Organism U4atac/U6atac SnRNP U6atac SnRNA Binding U6atac SnRNP [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Cell Killing U4/U6 SnRNP Hexosaminidase Activity Thrombospondin Receptor Activity ASAP Complex Catalytic Activity, Acting On A Protein Humoral Immune Response Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Transcription Elongation-coupled Chromatin Remodeling U4 SnRNA Binding Hyalurononglucosaminidase Activity Complement Activation, Lectin Pathway Transmembrane Transporter Complex Signaling Receptor Binding Negative Regulation Of Macrophage Migration Complement Activation, GZMK Pathway Immune Effector Process Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Astrocyte Differentiation Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis U6 SnRNA Binding Complement Activation, Alternative Pathway N-acetylglucosamine Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Spliceosomal Tri-snRNP Complex Assembly Fibrinolysis Ubiquitin-specific Protease Binding Protein Deglycosylation Negative Regulation Of Leukocyte Chemotaxis Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Inflammatory Response Negative Regulation Of Glial Cell Differentiation Hematopoietic Stem Cell Proliferation Positive Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Chemotaxis