SOX17

Name	SRY-box transcription factor 17
Structure
Novel Interactors	1 novel interactors: PKD1
Interactors	4 interactors: CTNNB1 HNF1B NFIC NFIX
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Endodermal Cell Fate Specification Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Gastrulation Endoderm Development Endodermal Cell Fate Determination Heart Development Tissue Development Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Response To Alkaloid Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Organ Development Embryonic Foregut Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Stem Cell Differentiation Stem Cell Fate Specification Protein Stabilization Endocardium Formation Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gallbladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Endodermal Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification Positive Regulation Of Stem Cell Differentiation
Pathways	Deactivation of the beta-catenin transactivating complex Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Diseases	Vesicoureteral reflux
GWAS	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Factor VIII levels ( 30586737 ) Intracranial aneurysm ( 20364137 33199917 18997786 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Pulmonary arterial hypertension ( 30527956 ) Total cholesterol levels ( 28334899 )
Entrez ID	64321
HPRD ID	18085
Ensembl ID	ENSG00000164736
Uniprot IDs	Q9H6I2
PDB IDs	2YUL 4A3N
GO Terms Enriched among Interactors ?	Genitalia Development Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Transcription By RNA Polymerase II Nephron Tubule Formation Epithelial Tube Morphogenesis Animal Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Nephron Tubule Morphogenesis Positive Regulation Of RNA Biosynthetic Process Kidney Morphogenesis Kidney Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of DNA-templated Transcription Renal Tubule Morphogenesis Hindbrain Development Positive Regulation Of RNA Metabolic Process Reproductive Structure Development Nephron Tubule Development Embryonic Epithelial Tube Formation Tube Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Pancreas Development Epithelium Development Epithelial Tube Formation Gland Development Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Tube Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Detection Of Mechanical Stimulus Morphogenesis Of An Epithelium Positive Regulation Of Macromolecule Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Skin Development Positive Regulation Of Biosynthetic Process Tissue Morphogenesis DNA-templated Transcription Lateral Plasma Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Odontogenesis Of Dentin-containing Tooth Kidney Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process