ATXN7

Name	ataxin 7
Structure
Novel Interactors	6 novel interactors: CPOX GNAT1 IMPDH2 PDHB SERINC3 SYNJ2
Interactors	58 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton Nuclear Matrix Transcription Factor TFTC Complex
	Molecular Function	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of DNA Repair Regulation Of Transcription By RNA Polymerase II Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways	HATs acetylate histones Ub-specific processing proteases
Diseases	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cataracts ( 34127677 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Estimated glomerular filtration rate ( 31152163 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 28991256 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 30054458 )
Entrez ID	6314
HPRD ID	06365
Ensembl ID	ENSG00000163635
Uniprot IDs	O15265 Q9UPD8
PDB IDs	2KKR 7KTR 7KTS 8H7G
GO Terms Enriched among Interactors ?	Extracellular Matrix Structural Constituent Integrin Binding Basement Membrane Identical Protein Binding Calcium Ion Binding Platelet Alpha Granule Lumen Extracellular Matrix Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Extracellular Region Cell-substrate Junction Assembly Microfibril Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell-substrate Junction Organization Pseudopodium Positive Regulation Of Protein Metabolic Process Transcription Factor TFTC Complex Positive Regulation Of Metabolic Process Ubiquitin-specific Protease Binding Cytoplasm Regulation Of Protein Catabolic Process Laminin Complex SAGA Complex Actin Filament Binding Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Focal Adhesion Assembly Regulation Of Cellular Component Organization Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Nervous System Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Post-embryonic Eye Morphogenesis Heparin Binding Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Basement Membrane Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Xenophagy Protein Complex Involved In Cell-matrix Adhesion