SAG

Name	S-antigen visual arrestin
Structure	No pdb structure
Novel Interactors	1 novel interactors: EIF4E2
Interactors	4 interactors: ADRA1B CHRM2 CLK3 RHO
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol Membrane Cell Projection
	Molecular Function	G Protein-coupled Receptor Binding Opsin Binding Protein Phosphatase Inhibitor Activity Protein Binding Spectrin Binding Phosphoprotein Binding
	Biological Process	G Protein-coupled Receptor Internalization Signal Transduction Cell Surface Receptor Signaling Pathway Sensory Perception G Protein-coupled Opsin Signaling Pathway
Pathways	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Diseases	Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP)
GWAS	Calcium levels ( 20705733 ) Crohn's disease ( 22412388 ) Estimated glomerular filtration rate ( 31152163 ) Mild obesity-related type 2 diabetes ( 34737425 )
Entrez ID	6295
HPRD ID	01625
Ensembl ID	ENSG00000130561
Uniprot IDs	P10523
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Alpha1-adrenergic Receptor Activity Regulation Of Heart Contraction Regulation Of Muscle Contraction G Protein-coupled Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuron-glial Cell Signaling G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway Rod Bipolar Cell Differentiation Photoreceptor Inner Segment Membrane 11-cis Retinal Binding Sperm Head Plasma Membrane Thermotaxis Absorption Of Visible Light MRNA Cap Binding Adrenergic Receptor Activity Regulation Of Blood Circulation Regulation Of Muscle System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Retinal Bipolar Neuron Differentiation Photoreceptor Activity Podosome Assembly Rod Photoreceptor Outer Segment Cholinergic Synapse Photoreceptor Outer Segment Membrane G Protein-coupled Photoreceptor Activity Phototransduction, Visible Light RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Golgi-associated Vesicle Membrane Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Light Intensity Glutamatergic Neuron Differentiation G Protein-coupled Acetylcholine Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Photoreceptor Disc Membrane Translation Factor Activity, RNA Binding Adrenergic Receptor Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Detection Of Temperature Stimulus Detection Of Visible Light Protein Serine/threonine/tyrosine Kinase Activity