EDA2R

Name	ectodysplasin A2 receptor
Structure	No pdb structure
Novel Interactors	1 novel interactors: SUFU
Interactors	16 interactors: AGR3 ATP6V0C C1QB CASP8 CATSPERH CEBPE EDA FADD GIMAP5 JAGN1 NKG7 PLP1 SGTA STRIT1 TRAF3 TRAF6
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Epidermis Development Ectodermal Cell Differentiation Cytokine-mediated Signaling Pathway Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways	TNFs bind their physiological receptors
GWAS	Balding ( 26926045 ) Male-pattern baldness ( 22032556 27182965 28196072 )
Entrez ID	60401
HPRD ID	02230
Ensembl ID	ENSG00000131080
Uniprot IDs	B2RBZ9 B4DQY6 Q9HAV5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Tumor Necrosis Factor Receptor Binding Death Receptor Binding Defense Response Death Effector Domain Binding Response To External Biotic Stimulus Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Myeloid Leukocyte Differentiation Death-inducing Signaling Complex Leukocyte Differentiation Regulation Of Proteolysis Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Signaling Adaptor Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Myeloid Cell Differentiation Positive Regulation Of Macrophage Differentiation Endosome Membrane Negative Regulation Of Necroptotic Process Positive Regulation Of Myeloid Cell Differentiation Cytoplasmic Side Of Plasma Membrane Immune System Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Response To Stress Regulation Of Myeloid Leukocyte Differentiation Mononuclear Cell Differentiation Tube Formation Regulation Of Macrophage Differentiation Innate Immune Response Granulocyte Differentiation Regulation Of Necroptotic Process Response To Other Organism Defense Response To Symbiont Regulation Of Programmed Necrotic Cell Death Cytokine-mediated Signaling Pathway Defense Response To Other Organism Immune Response Toll-like Receptor 4 Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Innate Immune Response Macrophage Differentiation Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation