ARHGAP22

Name	Rho GTPase activating protein 22
Structure	No pdb structure
Novel Interactors	5 novel interactors: ALG11 GPRIN2 MAPK8 PTPN20 ZNF488
Interactors	8 interactors: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS	Conduct disorder ( 20585324 ) Daytime sleep phenotypes ( 27126917 ) Diabetic retinopathy ( 21310492 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Macular thickness ( 30535121 ) Refractive error ( 32231278 ) Self-employment ( 23593239 ) Systolic blood pressure ( 31134134 ) Systolic blood pressure (education interaction) ( 31134134 )
Entrez ID	58504
HPRD ID	12476
Ensembl ID	ENSG00000128805
Uniprot IDs	A0A2X0SFC0 Q7Z5H3
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity