PTPN14

Name	protein tyrosine phosphatase non-receptor type 14
Structure
Interactors	7 interactors: CDH1 CTNNA2 CTNNB1 JUP TJP1 TRIP6 YWHAG
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton
	Molecular Function	Transcription Coregulator Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Receptor Tyrosine Kinase Binding
	Biological Process	Lymphangiogenesis Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Regulation Of Protein Export From Nucleus
Pathways	Interleukin-37 signaling
Diseases	Choanal atresia and lymphedema
GWAS	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Bone mineral density (hip) ( 30172743 ) Estimated glomerular filtration rate ( 31152163 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Height ( 25429064 28552196 31562340 ) Hip index ( 34021172 ) Lipid traits ( 24386095 ) Plasma thyroid-stimulating hormone levels ( 24722205 )
Entrez ID	5784
HPRD ID	04402
Ensembl ID	ENSG00000152104
Uniprot IDs	A8K6H6 Q15678
PDB IDs	2BZL 6IWD 6JJW
GO Terms Enriched among Interactors ?	Catenin Complex Cellular Response To Indole-3-methanol Response To Indole-3-methanol Anchoring Junction Cell Junction Organization Adherens Junction Cell Junction Assembly Cadherin Binding Cell-cell Junction Assembly Cell Adhesion Apical Junction Complex Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Adherens Junction Organization Desmosome Assembly Regulation Of Cell Adhesion Flotillin Complex Cell Adhesion Molecule Binding Alpha-catenin Binding Presynaptic Active Zone Cytoplasmic Component Regulation Of Cell Migration Focal Adhesion Regulation Of Cell Motility Desmosome Organization Regulation Of Locomotion Postsynaptic Density, Intracellular Component Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Lamellipodium Cell Junction Desmosome Basolateral Plasma Membrane Positive Regulation Of Protein Import Into Nucleus Synapse Organization Cell-cell Adhesion Mediated By Cadherin Response To Alcohol Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Regulation Of Anatomical Structure Morphogenesis Skin Development Intracellular Protein Localization Cellular Response To Oxygen-containing Compound Cell Migration Regulation Of Angiogenesis Regulation Of Protein Localization