SIPA1L2

Name	signal induced proliferation associated 1 like 2
Structure	No pdb structure
Interactors	4 interactors: AP3M1 ORC5 TCEANC TGM2
GO Annotations	Cellular Component	Cellular_component Cytoplasm Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Biological_process Regulation Of Small GTPase Mediated Signal Transduction Presynaptic Signal Transduction
GWAS	Age at first sexual intercourse ( 34211149 ) Alzheimer's disease ( 33074286 ) Bipolar disorder x sex interaction ( 34099189 ) Body size at age 10 ( 32376654 ) Immunoglobulin A ( 20694011 ) Parkinson's disease ( 25064009 28892059 32201043 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Post-traumatic stress disorder ( 24677629 ) PR interval ( 32439900 ) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531 ) Schizophrenia ( 30285260 ) Smooth-surface caries ( 24556642 )
Entrez ID	57568
HPRD ID	15346
Ensembl ID	ENSG00000116991
Uniprot IDs	A0A6Q8PH54 Q9P2F8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein Deamination Nuclear Origin Of Replication Recognition Complex Origin Recognition Complex Dopamine Secretion Cellular Response To Dopamine Cellular Response To Serotonin Salivary Gland Cavitation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Dopamine Protein-glutamine Gamma-glutamyltransferase Activity Catecholamine Secretion Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine AP-3 Adaptor Complex Branching Involved In Salivary Gland Morphogenesis Clathrin Adaptor Complex DNA Replication Origin Binding Endocytosis Peptide Cross-linking Cellular Response To Catecholamine Stimulus Anterograde Synaptic Vesicle Transport Melanosome Assembly Dopamine Transport Response To Catecholamine Mitochondrial Calcium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Cell Clearance Platelet Dense Granule Organization DNA Replication Initiation Positive Regulation Of Sprouting Angiogenesis Monoamine Transport Protein Targeting To Lysosome Vesicle Cargo Loading Import Into Cell Cellular Response To Alkaloid Synaptic Vesicle Transport Melanosome Organization Chromosome Pigment Granule Organization