ROR1

Name	receptor tyrosine kinase like orphan receptor 1
Structure
Novel Interactors	1 novel interactors: JUN
Interactors	14 interactors: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTN PTPN6 PTPRR STYX
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Cell Surface Membrane Axon Cell Projection Receptor Complex Axon Terminus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Signaling Receptor Activity Wnt Receptor Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Sensory Perception Of Sound Cell Population Proliferation Astrocyte Development Wnt Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
GWAS	Blood protein levels ( 30072576 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Pancreatic cancer ( 26098869 ) Severe bacterial meningitis ( 31092817 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Entrez ID	4919
HPRD ID	03821
Ensembl ID	ENSG00000185483
Uniprot IDs	Q01973
PDB IDs	5Z55 6BA5 6BAN 6TU9 7TNG
GO Terms Enriched among Interactors ?	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Regulation Of Epithelial Cell Migration Peptidyl-threonine Dephosphorylation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Response To Auditory Stimulus Negative Regulation Of Cell Communication Myeloid Leukocyte Activation Molecular Function Activator Activity Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Neuron Projection Regeneration Regulation Of Signal Transduction Microglial Cell Activation Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Synaptic Potentiation Response To Mechanical Stimulus Dendrite Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Protein Localization