ATP2B1

Name	ATPase plasma membrane Ca2+ transporting 1
Structure
Novel Interactors	2 novel interactors: DAO TRIM32
Interactors	7 interactors: CALM1 CCR2 CSNK2A1 ERBIN F2RL1 PRKACA PRKCA
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome Photoreceptor Ribbon Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Blood Pressure Positive Regulation Of Bone Mineralization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea
Drugs	Ritodrine Halothane Desflurane Sevoflurane
GWAS	Adult body size ( 32376654 ) Automobile speeding propensity ( 30643258 ) Biomedical quantitative traits ( 19396169 ) Blood pressure ( 21572416 21909110 24001895 24954895 ) Calcium levels ( 29403010 ) Chronotype ( 30696823 ) Coronary artery disease ( 29212778 32469254 26343387 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 22751097 ) Diastolic blood pressure ( 25249183 28739976 26390057 29403010 30487518 27841878 27618452 19430479 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure (long-term average) ( 28348047 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Diffusing capacity of carbon monoxide ( 30694715 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hypertension ( 30487518 31879980 32709000 31513605 28273873 25249183 19430479 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Magnesium levels ( 20700443 ) Mean arterial pressure ( 30487518 29403010 26390057 27618448 ) Mean arterial pressure (long-term average) ( 28348047 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Morning person ( 30696823 ) Myocardial infarction ( 33532862 26343387 ) Nonobstructive coronary artery disease ( 26534935 ) Pulse pressure ( 29403010 26390057 27841878 30578418 30487518 28739976 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 28739976 29403010 19430479 25249183 26390057 27618447 27618452 30578418 30487518 30224653 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure (long-term average) ( 28348047 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Total body bone mineral density ( 29304378 )
Entrez ID	490
HPRD ID	00158
Ensembl ID	ENSG00000070961
Uniprot IDs	P20020
PDB IDs	6A69
GO Terms Enriched among Interactors ?	Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Response To Peptide Response To Cytokine Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Chemokine Production Negative Regulation Of Cytokine Production Renal System Process Regulation Of Biological Quality Positive Regulation Of Protein Secretion Regulation Of Multicellular Organismal Process Calcium-mediated Signaling Signal Transduction Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Cycle Regulation Of Macroautophagy Negative Regulation Of Gene Expression Regulation Of Peptide Hormone Secretion Negative Regulation Of Immune System Process Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Insulin Secretion Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Regulation Of Exocytosis Negative Regulation Of Chemokine Production Regulation Of Secretion By Cell Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Locomotion Response To Stress Regulation Of Secretion Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Sperm Midpiece