NPHS1

Name	NPHS1 adhesion molecule, nephrin
Structure
Interactors	11 interactors: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Slit Diaphragm Cell Projection Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Myosin Binding Cell Adhesion Molecule Binding
	Biological Process	MAPK Cascade Cell Adhesion JNK Cascade Muscle Organ Development Skeletal Muscle Tissue Development Myoblast Fusion Gene Expression Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Slit Diaphragm Assembly Podocyte Development Cell-cell Adhesion
Pathways	Nephrin family interactions Nephrin family interactions
Diseases	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS	No GWAS studies recorded
Entrez ID	4868
HPRD ID	04094
Ensembl ID	ENSG00000161270
Uniprot IDs	O60500
PDB IDs	4ZRT
GO Terms Enriched among Interactors ?	Ephrin Receptor Signaling Pathway Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Actin Filament Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Complex Assembly Slit Diaphragm T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Motility Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Signaling Receptor Binding Immune Response-regulating Signaling Pathway Scaffold Protein Binding Activation Of Immune Response Response To Transforming Growth Factor Beta Regulation Of Cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cellular Response To Lectin Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Periphery Actin Filament Organization Positive Regulation Of Immune System Process Response To Growth Factor Protein Tyrosine Kinase Activity Regulation Of Cell Activation Transmembrane Transporter Binding Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress