NAIP

Name	NLR family apoptosis inhibitory protein
Structure
Interactors	3 interactors: CASP9 HPCA MAP3K7
GO Annotations	Cellular Component	Cytoplasm Basolateral Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex
	Molecular Function	Nucleotide Binding Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Serine/threonine Kinase Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Nervous System Development Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Pyroptotic Inflammatory Response
Diseases	Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS	No GWAS studies recorded
Entrez ID	4671
HPRD ID	09049
Ensembl ID	ENSG00000249437
Uniprot IDs	A0A0G2JNC7 A0A0G2JS53 B7ZLE8 Q13075
PDB IDs	2VM5 8FVU
GO Terms Enriched among Interactors ?	Response To Anesthetic Apoptosome Response To Hypoxia Glial Cell Apoptotic Process Response To Ketone Response To Oxygen Levels Response To Indole-3-methanol Intracellular Signal Transduction Response To Decreased Oxygen Levels Response To Metal Ion Caspase Complex Cellular Response To Oxygen-containing Compound Signal Transduction In Response To DNA Damage Identical Protein Binding Cellular Response To Hormone Stimulus Response To Aroclor 1254 Dendritic Spine Head Response To Ketamine I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding MAP Kinase Kinase Kinase Kinase Activity Histone Kinase Activity Positive Regulation Of CGAS/STING Signaling Pathway Interleukin-33-mediated Signaling Pathway Cellular Response To L-glutamate Protein Kinase Binding Response To Cobalt Ion Fibroblast Apoptotic Process Cellular Response To Electrical Stimulus Positive Regulation Of Cell Size Type II Transforming Growth Factor Beta Receptor Binding Positive Regulation Of JUN Kinase Activity Anoikis TRIF-dependent Toll-like Receptor Signaling Pathway ATAC Complex MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Cellular Response To Angiotensin Positive Regulation Of Execution Phase Of Apoptosis Response To L-glutamate Stimulatory C-type Lectin Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Cellular Response To Lectin Platelet Formation Response To Hormone