LMX1A

Name	LIM homeobox transcription factor 1 alpha
Structure
Interactors	5 interactors: BMPR2 ISL1 LDB1 LHX3 TCF3
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cell Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Central Nervous System Development Memory Locomotory Behavior Regulation Of Gene Expression Dentate Gyrus Development Cerebellum Development Hippocampus Development Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Olfactory Behavior Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation
GWAS	Age-related hearing impairment ( 34108613 ) Alcohol consumption (drinks per week) ( 30679032 ) Diffusing capacity of the lung for carbon monoxide traits ( 30049742 ) Hip circumference adjusted for BMI ( 34021172 ) Macular thickness ( 30535121 ) Pursuit maintenance gain ( 29064472 ) Response to acetaminophen (hepatotoxicity) ( 21177773 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Vestibular neuritis ( 30079052 )
Entrez ID	4009
HPRD ID	02623
Ensembl ID	ENSG00000162761
Uniprot IDs	Q8TE12
PDB IDs	8IK5 8IKE 8ILW
GO Terms Enriched among Interactors ?	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Pattern Specification Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Atrial Septum Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of RNA Metabolic Process Outflow Tract Septum Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process BHLH Transcription Factor Binding Neuron Fate Specification Pituitary Gland Development Transcription Cis-regulatory Region Binding Regionalization Cell Differentiation Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II System Development Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Neuron Differentiation Outflow Tract Morphogenesis Cellular Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cardiac Septum Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Fate Specification Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lung Development Stem Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis RNA Polymerase II Transcription Regulator Complex Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Activin Receptor Activity, Type II