KRT6A

Name	keratin 6A
Structure
Novel Interactors	12 novel interactors: CCR1 GNL1 KRT1 KRT3 KRT4 KRT5 KRT6B KRT7 PRPH RND1 TARBP2 TMBIM6
Interactors	37 interactors: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways	Keratinization Formation of the cornified envelope
Drugs	Zinc Zinc acetate
Diseases	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS	Cutaneous squamous cell carcinoma ( 32041948 )
Entrez ID	3853
HPRD ID	01011
Ensembl ID	ENSG00000205420
Uniprot IDs	A0A0S2Z428 P02538
PDB IDs	5KI0
GO Terms Enriched among Interactors ?	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway