ITPR2

Name	inositol 1,4,5-trisphosphate receptor type 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: PKP2
Interactors	5 interactors: BANK1 LINC01554 PRKACA TRPC1 TRPC4
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Transmembrane Transporter Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding
	Biological Process	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Signal Transduction Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Ethanol
Pathways	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs	Caffeine
GWAS	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 33547301 ) Amyotrophic lateral sclerosis ( 17827064 ) Birth weight ( 31043758 27680694 ) BRCA1/2-negative high-risk breast cancer ( 30323354 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels in HIV infection ( 33109212 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Kashin-Beck disease ( 25303641 ) LDL cholesterol levels ( 32203549 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte count ( 32888494 ) Major depressive disorder ( 27479909 ) Male-pattern baldness ( 27182965 ) Offspring birth weight ( 31043758 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 31231134 22010048 ) Retinitis pigmentosa ( 33514863 ) Serum alkaline phosphatase levels ( 33547301 ) Smooth-surface caries ( 24556642 ) Type 2 diabetes ( 30297969 30054458 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 20935629 25673412 ) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 )
Entrez ID	3709
HPRD ID	02536
Ensembl ID	ENSG00000123104
Uniprot IDs	Q14571
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Channel Complex Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Regulation Of Heart Contraction Regulation Of Cardiac Conduction Calcium Channel Complex Regulation Of Blood Circulation Regulation Of Metal Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Maintenance Of Protein Localization At Cell Tip Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intracellular Chemical Homeostasis Regulation Of System Process Regulation Of Sequestering Of Calcium Ion Transmembrane Transporter Binding Cellular Homeostasis Regulation Of Calcium Ion Transmembrane Transport Maintenance Of Animal Organ Identity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Monoatomic Ion Channel Activity Regulation Of Muscle Contraction Positive Regulation Of Monoatomic Ion Transport Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Intracellular Calcium Ion Homeostasis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Positive Regulation Of Transport Cell-cell Junction CAMP-dependent Protein Kinase Activity Calcium Ion Transmembrane Transport Gamma-aminobutyric Acid Secretion Chemical Homeostasis Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Calcium Ion Transport Channel Activator Activity