ITPK1

Name	inositol-tetrakisphosphate 1-kinase
Structure
Interactors	6 interactors: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Catalytic Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Isomerase Activity Metal Ion Binding Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity
	Biological Process	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Necroptotic Process
Pathways	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
GWAS	Body mass index ( 26426971 ) Chronic obstructive pulmonary disease ( 30804561 ) Endometriosis ( 23472165 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 31562340 ) Migraine ( 27182965 27322543 ) Monocyte count ( 32888494 ) Platelet count ( 22139419 32888494 ) Plateletcrit ( 27863252 32888494 ) Spleen volume ( 34128465 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) White blood cell count ( 32888494 )
Entrez ID	3705
HPRD ID	03501
Ensembl ID	ENSG00000100605
Uniprot IDs	G3V4M9 Q13572
PDB IDs	2ODT 2Q7D 2QB5 9DN3
GO Terms Enriched among Interactors ?	Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Ubiquitin Protein Ligase Binding Tumor Necrosis Factor-mediated Signaling Pathway Enzyme Binding Protein Deneddylation General Transcription Initiation Factor Binding Regulation Of Protein Neddylation Protein Neddylation Programmed Necrotic Cell Death Response To Muscle Stretch COP9 Signalosome Response To Endoplasmic Reticulum Stress Non-canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Nucleoplasm Positive Regulation Of MiRNA Transcription JNK Cascade Transcription Repressor Complex Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Cytokine-mediated Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition TORC2 Complex Disassembly Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Leukocyte Activation Positive Regulation Of Apoptotic Process Leading Edge Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Oligodendrocyte Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Import Into Nucleus Regulation Of Protein Modification Process