ACADVL

Name	acyl-CoA dehydrogenase very long chain
Structure
Interactors	5 interactors: GPHN LINC01554 RPSA SOCS3 TAF1B
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Mitochondrial Nucleoid
	Molecular Function	Fatty-acyl-CoA Binding Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Temperature Homeostasis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Catabolic Process Response To Cold Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process
Pathways	XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Diseases	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS	Age-related hearing impairment ( 34108613 ) Metabolite levels ( 23823483 )
Entrez ID	37
HPRD ID	01940
Ensembl ID	ENSG00000072778
Uniprot IDs	B3KPA6 P49748
PDB IDs	2UXW 3B96 7S7G
GO Terms Enriched among Interactors ?	RNA Polymerase I Core Factor Complex Glycine Receptor Clustering Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity Laminin Receptor Activity RNA Polymerase Transcription Factor SL1 Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I Transcription Regulator Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Specialization, Intracellular Component Molybdopterin Cofactor Binding Nitrate Reductase Activity Molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Gamma-aminobutyric Acid Receptor Clustering Cellular Response To Interleukin-17 Protein Tyrosine Kinase Inhibitor Activity Glycinergic Synapse RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Branching Involved In Labyrinthine Layer Morphogenesis Postsynaptic Specialization T-helper 17 Cell Lineage Commitment Neurotransmitter-gated Ion Channel Clustering Ribosomal Small Subunit Assembly Inhibitory Synapse Transcription By RNA Polymerase I Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Laminin Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Lineage Commitment Small Ribosomal Subunit TBP-class Protein Binding RRNA Transcription CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cytokine Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Placenta Blood Vessel Development T Cell Lineage Commitment Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Synaptic Transmission, GABAergic