HOXA11

Name	homeobox A11
Structure	No pdb structure
Interactors	5 interactors: CREBBP GMNN MEIS1 PGBD3 YY1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Chondrocyte Differentiation Chondrocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Prostate Gland Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Response To Testosterone Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Response To Estrogen Positive Regulation Of DNA-templated Transcription Cell Development Developmental Growth Uterus Development Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Chondrocyte Development
Pathways	Formation of the ureteric bud
Diseases	Radioulnar synostosis with amegakaryocytic thrombocytopenia
GWAS	A body shape index ( 34021172 ) Heel bone mineral density ( 30598549 28869591 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 25673412 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )
Entrez ID	3207
HPRD ID	00846
Ensembl ID	ENSG00000005073
Uniprot IDs	P31270
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Chromatin Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of DNA Metabolic Process Cellular Response To UV Anatomical Structure Morphogenesis Sequence-specific DNA Binding Animal Organ Morphogenesis Recombinational Repair Positive Regulation Of DNA Repair Histone H3K18 Acetyltransferase Activity Response To UV N-terminal Peptidyl-lysine Acetylation Cellular Response To Light Stimulus Double-strand Break Repair Via Homologous Recombination Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Immunoglobulin Heavy Chain V-D-J Recombination Response To Prostaglandin F Regulation Of DNA Replication DNA Replication Preinitiation Complex Assembly Cellular Response To Radiation Hemopoiesis MRF Binding Transcription Corepressor Activity Double-strand Break Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Chromatin Binding Chromatin Immunoglobulin V(D)J Recombination Positive Regulation Of DNA Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Peptidyl-lysine Acetylation Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Heat Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Response To Light Stimulus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Definitive Hemopoiesis Lens Morphogenesis In Camera-type Eye Regulation Of DNA Strand Elongation Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding