HMGCR

Name	3-hydroxy-3-methylglutaryl-CoA reductase
Structure
Interactors	5 interactors: ARHGAP1 INSIG1 PRKACA STARD13 TMUB1
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor GTPase Regulator Activity NADP Binding NADPH Binding Coenzyme A Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Visual Learning Coenzyme A Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Long-term Synaptic Potentiation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Amyloid-beta Clearance
Pathways	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs	NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
GWAS	Apolipoprotein B levels ( 32203549 ) Body mass index ( 20935630 ) Cholesterol ( 31902109 ) Cholesterol, total ( 19060911 28270201 20686565 26582766 25961943 24097068 ) Coronary artery disease ( 33020668 ) LDL cholesterol ( 18802019 26582766 25961943 24097068 18193044 20864672 20686565 19060906 19060911 ) LDL cholesterol levels ( 32203549 28334899 31087446 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipid traits ( 24386095 ) Low density lipoprotein cholesterol levels ( 29403010 32154731 33339817 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 21909109 23823483 ) Quantitative traits ( 19197348 ) Total cholesterol levels ( 31087446 30275531 28334899 33339817 ) Type 2 diabetes ( 32499647 )
Entrez ID	3156
HPRD ID	00836
Ensembl ID	ENSG00000113161
Uniprot IDs	P04035
PDB IDs	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB 8PKN 8S6B
GO Terms Enriched among Interactors ?	Regulation Of Intracellular Transport Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Intracellular Transport Regulation Of Steroid Biosynthetic Process Regulation Of Cellular Localization Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Endothelial Tube Lumen Extension Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Endocytic Recycling Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Cellular Response To Peptide Hormone Stimulus Regulation Of Lipid Biosynthetic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Negative Regulation Of SREBP Signaling Pathway Sorting Endosome CAMP-dependent Protein Kinase Activity Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Intracellular Transport GTPase Activator Activity Protein Transport Regulation Of Lipid Metabolic Process Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Cranial Suture Morphogenesis Response To Sterol Depletion Negative Regulation Of Protein Exit From Endoplasmic Reticulum Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Small Molecule Metabolic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Cellular Response To Sterol Depletion CAMP-dependent Protein Kinase Complex