HK1

Name	hexokinase 1
Structure
Novel Interactors	1 novel interactors: USP54
Interactors	6 interactors: APP CFTR ENO2 SCMH1 VDAC1 VDAC2
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Membrane Raft
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Peptidoglycan Binding Glucosamine Kinase Activity
	Biological Process	Intracellular Glucose Homeostasis Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response GDP-mannose Biosynthetic Process Hexose Metabolic Process Organophosphate Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis GDP-mannose Biosynthetic Process From Mannose Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process
Pathways	Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS	Apolipoprotein B levels ( 32203549 ) Birth weight ( 31043758 ) Glycated hemoglobin levels ( 34059833 19096518 31213470 29483669 28898252 20858683 ) Glycemic traits (pregnancy) ( 23903356 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 19862010 32888494 27863252 ) Hemoglobin ( 32888494 19862010 ) Hemoglobin A1c levels ( 29844224 31217584 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 28017375 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Iris color (a* coordinate) ( 29109912 ) Iris color (b* coordinate) ( 29109912 ) Iron status biomarkers (ferritin levels) ( 33536631 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean corpuscular hemoglobin ( 20139978 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 20139978 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Offspring birth weight ( 31043758 ) Plateletcrit ( 32888494 ) Red blood cell count ( 27863252 32888494 20139978 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )
Entrez ID	3098
HPRD ID	00809
Ensembl ID	ENSG00000156515
Uniprot IDs	A0A994J753 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
GO Terms Enriched among Interactors ?	Membrane Raft Voltage-gated Monoatomic Anion Channel Activity Porin Activity Ceramide Binding Voltage-gated Monoatomic Ion Channel Activity Pore Complex Monoatomic Anion Transmembrane Transport Oxysterol Binding Monoatomic Anion Transport Mitochondrial Transmembrane Transport Phosphatidylcholine Binding Mitochondrial Transport Regulation Of Monoatomic Ion Transmembrane Transport Mitochondrial Nucleoid Cholesterol Binding Lipid Transport Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Anion Channel Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Calcium Import Into The Mitochondrion Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process