HADH

Name	hydroxyacyl-CoA dehydrogenase
Structure
Interactors	8 interactors: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Identical Protein Binding NAD+ Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Spermatogenesis Response To Xenobiotic Stimulus Response To Hormone Response To Activity Cell Differentiation Response To Insulin Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis
Pathways	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial protein degradation
Drugs	NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids
Diseases	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 )
Entrez ID	3033
HPRD ID	08372
Ensembl ID	ENSG00000138796
Uniprot IDs	A0A0D9SFP2 A0A140VK76 B3KTT6 Q16836
PDB IDs	1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS
GO Terms Enriched among Interactors ?	Butanol Dehydrogenase (NAD+) Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Peptide Clathrin-coated Pit Protein-containing Complex Response To Cytokine Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Circulatory System Process Cellular Response To Type II Interferon Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona SCF Ubiquitin Ligase Complex Lewy Neurite Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Signaling Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Response To Cytokine Stimulus GBD Domain Binding