PCLO

Name	piccolo presynaptic cytomatrix protein
Structure
Interactors	6 interactors: ERC2 GIT1 GIT2 PCAT1 SNCA TMEM132D
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Cell Projection Organelle Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Zinc Ion Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Regulation Of Transport Regulation Of Biological Quality Synaptic Vesicle Clustering Presynaptic Actin Cytoskeleton Organization Presynapse Organization Presynaptic Active Zone Assembly
Pathways	Sensory processing of sound by inner hair cells of the cochlea
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Energy expenditure (24h) ( 28476931 ) Grapefruit juice consumption ( 31046077 ) HDL cholesterol levels in HIV infection ( 33109212 ) Major depressive disorder ( 20351715 21621269 28540843 ) Metabolite levels ( 23823483 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Refractive error ( 32231278 ) Rosacea symptom severity ( 29771307 ) Schizophrenia ( 33169155 )
Entrez ID	27445
HPRD ID	16078
Ensembl ID	ENSG00000186472
Uniprot IDs	Q9Y6V0
PDB IDs	1UJD
GO Terms Enriched among Interactors ?	Presynapse Regulation Of G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Priming Growth Cone Synaptic Vesicle Recycling Regulation Of ARF Protein Signal Transduction Maintenance Of Synapse Structure Regulation Of Vesicle Fusion Synapse Organization Synapse Cell Junction Maintenance Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of SNARE Complex Assembly Regulation Of Microtubule Polymerization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Cellular Component Maintenance Negative Regulation Of ARF Protein Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization GABA-ergic Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Structural Constituent Of Postsynaptic Specialization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Exocytosis Locomotory Behavior Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Intramembranous Ossification Response To Iron(II) Ion Calcium Ion Homeostasis Structural Constituent Of Presynaptic Active Zone Motor Learning Regulation Of Chaperone-mediated Autophagy Postsynapse Regulation Of Dopamine Uptake Involved In Synaptic Transmission