GLI3

Name	GLI family zinc finger 3
Structure
Interactors	19 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Kidney Development Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Smoothened Signaling Pathway Pattern Specification Process Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Hindgut Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Gene Expression Regulation Of Gene Expression Protein Processing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Telencephalon Development Pallium Development Subpallium Development Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia-guided Migration Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Embryonic Limb Morphogenesis Mammary Gland Development Forebrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Tube Development Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Negative Thymic T Cell Selection Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Neurocranium Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Roof Of Mouth Development Limb Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Larynx Morphogenesis Regulation Of Bone Development Negative Regulation Of Stem Cell Proliferation
Pathways	GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation
Diseases	Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome
GWAS	Age-related macular degeneration ( 23326517 ) Allergic rhinitis ( 22036096 ) Appendicular lean mass ( 33097823 ) Asthma ( 29273806 ) Dietary fat liking ( 32516399 ) Digit length ratio ( 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Emotional recognition ( 31596458 ) facial morphology traits (multivariate analysis) ( 27193062 ) Health literacy ( 31250787 ) Hip index ( 34021172 ) Language performance in older adults (adjusted for episodic memory) ( 28577822 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean arterial pressure (alcohol consumption interaction) ( 24376456 ) Metabolite levels ( 23823483 ) middle facial morphology traits (quantitative measurement) ( 27193062 ) Refractive error ( 32231278 ) Response to resistance training (vastus lateralis fiber area change) ( 33891350 )
Entrez ID	2737
HPRD ID	01313
Ensembl ID	ENSG00000106571
Uniprot IDs	A0A2R8YGX0 P10071
PDB IDs	4BLD
GO Terms Enriched among Interactors ?	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process I-SMAD Binding Regulation Of Primary Metabolic Process Animal Organ Development Positive Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Binding Regulation Of Smoothened Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Endoderm Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catabolic Process Tissue Morphogenesis Transcription Regulator Complex Gastrulation Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Co-SMAD Binding DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Primary MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Nucleoplasm