GAP43

Name	growth associated protein 43
Structure	No pdb structure
Novel Interactors	2 novel interactors: CD47 LOX
Interactors	8 interactors: CALM1 CSNK2A1 ELAVL4 PLCD1 PRKCB PRKCD RABEP1 SPTAN1
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Filopodium Membrane Growth Cone Membrane Cell Projection Perikaryon Synapse Cell Periphery Presynapse GABA-ergic Synapse
	Molecular Function	Phosphatidylserine Binding Protein Binding Calmodulin Binding Lysophosphatidic Acid Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Nervous System Development Axon Guidance Response To Wounding Response To Auditory Stimulus Axon Choice Point Recognition Cell Differentiation Axon Regeneration Regulation Of Growth Tissue Regeneration Cell Fate Commitment Astrocyte Differentiation Regulation Of Filopodium Assembly Radial Glial Cell Differentiation Regulation Of Postsynaptic Specialization Assembly
Pathways	L1CAM interactions
GWAS	Borderline personality disorder ( 28632202 ) Breast size ( 22747683 ) Metabolite levels ( 23823483 ) Proliferative diabetic retinopathy ( 31482010 ) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 ) Seasonality and depression ( 30217971 ) Urate levels in obese individuals ( 25811787 )
Entrez ID	2596
HPRD ID	01198
Ensembl ID	ENSG00000172020
Uniprot IDs	P17677 Q5U058
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Kinase C Signaling Phospholipase C/protein Kinase C Signal Transduction Spectrin Diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Cell Death Apoptotic Process Programmed Cell Death Presynaptic Cytosol Regulation Of Biological Quality Calcium Channel Regulator Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Actin Filament Polymerization Descending Aorta Development Ascending Aorta Development Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cellular Response To Interleukin-12 Protein Serine Kinase Activity Pre-mRNA Intronic Pyrimidine-rich Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3T6 Kinase Activity Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Supramolecular Fiber Organization Negative Regulation Of Transport Response To Type II Interferon Cellular Response To Cytokine Stimulus Protein Kinase CK2 Complex Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Peptidyl-lysine Oxidation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Transmembrane Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion