FUCA1

Name	alpha-L-fucosidase 1
Structure
Interactors	8 interactors: APP BARD1 CIB1 MED10 OGT PAXIP1 UBQLN2 VAV2
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Carbohydrate Metabolic Process Fucose Metabolic Process Lipid Metabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process
Pathways	Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway
Diseases	Fucosidosis
GWAS	Arterial stiffness index ( 31235810 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Entrez ID	2517
HPRD ID	01974
Ensembl ID	ENSG00000179163
Uniprot IDs	P04066
PDB IDs	7PLS 7PM4
GO Terms Enriched among Interactors ?	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of ATP Metabolic Process Intracellular Signal Transduction Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Proteolysis Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Response To Radiation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity