SLC7A11

Name	solute carrier family 7 member 11
Structure
Interactors	7 interactors: BAAT KRTAP1-1 KRTAP1-3 PCBP2 SLC3A2 TERT ZRANB1
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Brush Border Membrane Microvillus Membrane Cell Projection Apical Part Of Cell Astrocyte Projection
	Molecular Function	Protein Binding L-amino Acid Transmembrane Transporter Activity Cystine:glutamate Antiporter Activity Transmembrane Transporter Activity L-kynurenine Transmembrane Transporter Activity
	Biological Process	Amino Acid Transmembrane Transport Glutathione Metabolic Process Amino Acid Transport Brain Development Visual Learning Response To Toxic Substance L-cystine Transport L-glutamate Transmembrane Transport Ventricular System Development Striatum Development Adult Behavior Regulation Of Neutrophil Apoptotic Process Cellular Response To Stress Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Melanin Biosynthetic Process Lung Alveolus Development Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Regulation Of Protein Transport Response To Redox State Transmembrane Transport Limb Development Platelet Aggregation Intracellular Glutamate Homeostasis L-glutamate Import Across Plasma Membrane Negative Regulation Of Ferroptosis Dipeptide Import Across Plasma Membrane L-kynurenine Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Regulation Of Cysteine Metabolic Process Regulation Of Glutathione Biosynthetic Process Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Glutamate Metabolic Process
Pathways	Basigin interactions Amino acid transport across the plasma membrane NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs	Cystine Glutamic acid Riluzole Sulfasalazine Acetylcysteine Thimerosal
GWAS	Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Mood instability ( 31168069 ) Neurociticism ( 29500382 ) Sleep duration (> 10 hours) ( 33075057 )
Entrez ID	23657
HPRD ID	09720
Ensembl ID	ENSG00000151012
Uniprot IDs	Q9UPY5
PDB IDs	7CCS 7EPZ 7P9U 7P9V
GO Terms Enriched among Interactors ?	Glycine N-choloyltransferase Activity Bile Acid Conjugation Apical Pole Of Neuron TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Medium-chain Fatty Acyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Exogenous Protein Binding Amino Acid Transport Complex Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Keratin Filament Methionine Transport L-leucine Import Across Plasma Membrane Aromatic Amino Acid Transmembrane Transporter Activity Tyrosine Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity L-histidine Transport Phenylalanine Transport Valine Transport L-alanine Import Across Plasma Membrane Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Isoleucine Transport L-leucine Transmembrane Transporter Activity L-alanine Transmembrane Transport Tryptophan Transport Protein K33-linked Deubiquitination Intermediate Filament Promoter-enhancer Loop Anchoring Activity L-alanine Transmembrane Transporter Activity Positive Regulation Of Protein Localization To Nucleolus Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral RNA Genome Replication Telomerase Activity Establishment Of Protein Localization To Telomere L-alanine Transport SiRNA Processing N-acyltransferase Activity Thiolester Hydrolase Activity L-leucine Transport Proline Transport Nuclear Telomere Cap Complex Taurine Metabolic Process