FNTB

Name	farnesyltransferase, CAAX box, subunit beta
Structure
Interactors	17 interactors: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRABD3 KRAS PTP4A3 RAP2A RRAS2 SMG9 TLX3
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Peptide Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Cell Population Proliferation Protein Farnesylation Positive Regulation Of Cell Cycle Regulation Of Microtubule-based Movement
Pathways	Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs	AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
GWAS	Blood trace element (Zn levels) ( 23720494 ) Eosinophil count ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mean corpuscular hemoglobin ( 27863252 32888494 28017375 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 19862010 32888494 28017375 27863252 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Neutrophil count ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Entrez ID	2342
HPRD ID	00608
Ensembl ID	ENSG00000257365
Uniprot IDs	A0A384MEJ5 P49356
PDB IDs	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
GO Terms Enriched among Interactors ?	GDP Binding G Protein Activity GTPase Activity GTP Binding Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Dynein Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Defense Response To Protozoan Regulation Of Rac Protein Signal Transduction Regulation Of Protein Localization To Membrane Microtubule Associated Complex Response To Protozoan Hydrolase Activity Protein-membrane Adaptor Activity Response To Mineralocorticoid L-serine-pyruvate Transaminase Activity Peptide Pheromone Maturation Alpha-tubulin Binding Hsp90 Protein Binding Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Oxalic Acid Secretion Microtubule Binding CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Movement Protein Farnesyltransferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Protein Farnesyltransferase Complex Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Glial Cell Development GTPase Complex Regulation Of Dendrite Morphogenesis Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Small GTPase Mediated Signal Transduction Glyoxylate Catabolic Process Alanine-glyoxylate Transaminase Activity Protein Farnesylation