CRTC1

Name	CREB regulated transcription coactivator 1
Structure
Novel Interactors	1 novel interactors: PLAT
Interactors	5 interactors: CREB1 MAP3K1 SRPK2 TBK1 YWHAG
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body
	Molecular Function	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Memory Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Cellular Response To CAMP Energy Homeostasis Negative Regulation Of Membrane Hyperpolarization
Pathways	Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
GWAS	Adult body size ( 32376654 ) Barrett's esophagus ( 24121790 ) Barrett's esophagus or Esophageal adenocarcinoma ( 32918910 27527254 ) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910 ) Body fat percentage ( 26833246 ) Body mass index ( 28448500 28552196 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790 ) Esophageal adenocarcinoma ( 24121790 ) Estimated glomerular filtration rate ( 31152163 ) Gastroesophageal reflux disease ( 31527586 34187846 ) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401 ) Menarche (age at onset) ( 21102462 25231870 ) Walking pace ( 33128006 )
Entrez ID	23373
HPRD ID	06339
Ensembl ID	ENSG00000105662
Uniprot IDs	Q6UUV9
PDB IDs	7D8H 7D8P 7D9V
GO Terms Enriched among Interactors ?	Protein Modification Process Protein Phosphorylation Phosphorylation Protein Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Phosphoprotein Binding Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation MRNA Transcription Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Chemotaxis To Arachidonate TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Modulation Of Chemical Synaptic Transmission Phosphate-containing Compound Metabolic Process Macromolecule Metabolic Process Protein Kinase Activity Regulation Of TORC1 Signaling Regulation Of Translational Initiation Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Cytoplasmic Translation MRNA Metabolic Process Kinase Activity Response To Dehydroepiandrosterone Regulation Of Immune System Process Response To Stress Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein Kinase C Inhibitor Activity Dendritic Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of TOR Signaling Positive Regulation Of Translation ATF4-CREB1 Transcription Factor Complex Response To Hypobaric Hypoxia Trans-synaptic Signaling By BDNF Nuclear Speck Organization Cellular Response To Peptide Hormone Stimulus Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly