DAAM1

Name	dishevelled associated activator of morphogenesis 1
Structure
Novel Interactors	1 novel interactors: KIAA0586
Interactors	7 interactors: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA USP10
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Motile Cilium Ciliary Basal Body Cell Projection Synapse Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Wnt Signaling Pathway Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Presynaptic Actin Cytoskeleton Organization
Pathways	PCP/CE pathway RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
GWAS	Brain morphology (MOSTest) ( 32665545 ) Cortical surface area ( 32963231 ) Cortical surface area (visual PC2) ( 32198502 ) Cortical thickness ( 32963231 ) Cortical volume ( 32963231 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inferior temporal gyrus volume ( 31530798 ) Left–right brain asymmetry ( 33723403 ) Occipital lobe volume ( 31396565 ) Optic disc size ( 31809533 ) Parietal lobe volume ( 31396565 ) Parkinsonism in frontotemporal lobe dementia ( 29724592 ) Type 2 diabetes ( 25483131 )
Entrez ID	23002
HPRD ID	09433
Ensembl ID	ENSG00000100592
Uniprot IDs	Q9Y4D1
PDB IDs	2J1D 2Z6E
GO Terms Enriched among Interactors ?	Wnt Signaling Pathway, Planar Cell Polarity Pathway Convergent Extension Involved In Neural Plate Elongation Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Organogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Neuron Projection Arborization Epithelial Tube Morphogenesis Convergent Extension Regulation Of Neuron Projection Arborization Cochlea Morphogenesis Frizzled Binding Regulation Of Cell Morphogenesis Wnt Signaling Pathway Cytochrome C Metabolic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cytoplasmic Microtubule Organization Tube Morphogenesis Mitotic Cleavage Furrow Formation Morphogenesis Of An Epithelium Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Ganglioside Galactosyltransferase Activity Clathrin-coated Vesicle Calcium Oxalate Binding Aortic Valve Formation Protein Kinase Binding Positive Regulation Of Vascular Associated Smooth Muscle Contraction Tissue Morphogenesis Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Regulation Of Cytokinesis Positive Regulation Of Protein Localization To Presynapse Canonical Wnt Signaling Pathway Negative Regulation Of Stress Granule Assembly Collagen Fibril Binding IgA Binding Beta Selection Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Cytochrome Metabolic Process Bone Trabecula Morphogenesis Regulation Of JNK Cascade Dendritic Spine Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Matrix Side Of Mitochondrial Inner Membrane Organelle Organization Regulation Of Cell Division Regulation Of Systemic Arterial Blood Pressure By Endothelin