PIKFYVE

Name	phosphoinositide kinase, FYVE-type zinc finger containing
Structure
Interactors	6 interactors: APP CDK5 H3C1 MIR140 RABEPK VAC14
GO Annotations	Cellular Component	Golgi Membrane Endosome Cytosol Endosome Membrane Vesicle Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Membrane Raft
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Metal Ion Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity
	Biological Process	Protein Targeting To Membrane Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Intracellular Protein Localization Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Metabolic Process Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Diseases	Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS	Adult asthma ( 27611488 ) Post bronchodilator FEV1 ( 26634245 )
Entrez ID	200576
HPRD ID	17852
Ensembl ID	ENSG00000115020
Uniprot IDs	Q9Y2I7
PDB IDs	7K2V
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Endocytosis Regulation Of Receptor Internalization Glial Cell Development Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration PAS Complex PTB Domain Binding Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Positive Regulation Of Programmed Cell Death Regulation Of Chemokine Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Vesicle-mediated Transport Perikaryon Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Adult Behavior Regulation Of Interleukin-6 Production Axonogenesis Learning