JAG1

Name	jagged canonical Notch ligand 1
Structure
Novel Interactors	1 novel interactors: SH2D4A
Interactors	9 interactors: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Apical Part Of Cell
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity Molecular Adaptor Activity
	Biological Process	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet Inhibition Of Neuroepithelial Cell Differentiation T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Cell Communication Notch Signaling Pathway Nervous System Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell-cell Adhesion Hemopoiesis Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Neuroendocrine Cell Differentiation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Podocyte Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation
Pathways	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Nephron development
Diseases	Tetralogy of Fallot Alagille syndrome
GWAS	Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 27680694 ) Blood pressure ( 21909110 ) Bone mineral density ( 20096396 ) Bone mineral density (spine) ( 30172743 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac hypertrophy ( 21348951 ) Cataracts ( 34127677 ) Cataracts (operation) ( 31816047 ) Diastolic blood pressure ( 21909115 27618447 27618452 26390057 27841878 25249183 28135244 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Eosinophil count ( 32888494 ) Frontotemporal dementia (age at onset) ( 29724592 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) Heel bone mineral density ( 30598549 28869591 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Lumbar spine bone mineral density ( 22504420 29499414 ) Lymphocyte count ( 32888494 ) Migraine ( 27322543 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 28135244 ) Red blood cell count ( 32888494 ) Systolic blood pressure ( 28739976 28135244 27841878 25249183 27618452 21909115 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Type 2 diabetes ( 28828242 ) Urate levels ( 31578528 ) Urinary bladder cancer ( 24861552 )
Entrez ID	182
HPRD ID	03562
Ensembl ID	ENSG00000101384
Uniprot IDs	P78504 Q99740
PDB IDs	2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1
GO Terms Enriched among Interactors ?	Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Angiogenesis Cellular Response To Tumor Cell Pattern Specification Process Negative Regulation Of Endothelial Cell Chemotaxis Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Left/right Axis Specification Epithelial Tube Morphogenesis Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Renal Tubule Development Anterior/posterior Pattern Specification Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mature B Cell Differentiation Involved In Immune Response Regulation Of Neuron Differentiation NF-kappaB Binding Mature B Cell Differentiation Receptor Complex Inflammatory Response To Antigenic Stimulus Sprouting Angiogenesis Positive Regulation Of BMP Signaling Pathway Neuron Fate Commitment Neuron Projection Guidance Axon Guidance Positive Regulation Of Notch Signaling Pathway Calcium Ion Binding Golgi Membrane Regulation Of Smooth Muscle Cell Differentiation In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Somitogenesis Chordate Embryonic Development Cell Surface Negative Regulation Of Chemotaxis Signal Transduction