DYNC1I2

Name	dynein cytoplasmic 1 intermediate chain 2
Structure
Novel Interactors	5 novel interactors: ACTN3 ATP5MC3 CDCA7 HOXD1 HOXD8
Interactors	8 interactors: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Microtubule-based Movement Transport Along Microtubule Positive Regulation Of Intracellular Transport
Pathways	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
GWAS	Hippocampal volume ( 25625606 ) Metabolite levels ( 23823483 ) Refractive error ( 32231278 ) Weight ( 28552196 )
Entrez ID	1781
HPRD ID	04512
Ensembl ID	ENSG00000077380
Uniprot IDs	A0A140VKE9 B4DPZ3 Q13409
PDB IDs	5JPW 6F1T 6F1U 6F1Z 6F38 6F3A 7Z8F 7Z8I 7Z8J 7Z8K 8PQW 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
GO Terms Enriched among Interactors ?	Dynein Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Microtubule Microtubule-based Movement Microtubule-based Process Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Regulation Of Cellular Localization Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Establishment Of Spindle Localization Spindle Localization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Axon Mitotic Spindle Astral Microtubule Spine Apparatus Type 5 Metabotropic Glutamate Receptor Binding Hemi-methylated DNA-binding