DYNC1I2 and CDCA7

		DYNC1I2	CDCA7
Description		dynein cytoplasmic 1 intermediate chain 2	cell division cycle associated 7
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Protein Binding Hemi-methylated DNA-binding
	Biological Process	Microtubule-based Movement Transport Along Microtubule Positive Regulation Of Intracellular Transport	Regulation Of DNA-templated Transcription Apoptotic Process Regulation Of Cell Population Proliferation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Breast cancer ( 23535729 29059683) End-stage renal disease in Type 1 diabetics ( 24029427) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Male-pattern baldness ( 27182965 29146897) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) Prostate cancer ( 29892016) Sensation seeking ( 30718321)
Interacting Genes		8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1	1 interacting genes: APP
Entrez ID		1781	83879
HPRD ID		04512	09874
Ensembl ID		ENSG00000077380	ENSG00000144354
Uniprot IDs		A0A140VKE9 B4DPZ3 Q13409	Q9BWT1
PDB IDs		5JPW 6F1T 6F1U 6F1Z 6F38 6F3A 7Z8F 7Z8I 7Z8J 7Z8K 8PQW 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK	8TLK 8YV8
Enriched GO Terms of Interacting Partners?		Dynein Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Microtubule Microtubule-based Movement Microtubule-based Process Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Regulation Of Cellular Localization Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Establishment Of Spindle Localization Spindle Localization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Axon Mitotic Spindle Astral Microtubule Spine Apparatus Type 5 Metabotropic Glutamate Receptor Binding Hemi-methylated DNA-binding	Golgi Ribbon Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Microtubule-based Transport Transport Along Microtubule Amylin Binding Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Microtubule-based Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Glycosylation Golgi Organization Asymmetric Golgi Ribbon Formation Golgi Vesicle Budding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Protein Complex Oligomerization Intracellular Transport NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Transport Golgi Disassembly Axon Choice Point Recognition Regulation Of Protein Glycosylation
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