NKX2-3

Name	NK2 homeobox 3
Structure	No pdb structure
Interactors	3 interactors: GTF2A1L SRF ZNF212
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Fate Specification Leukocyte Homeostasis Plasma Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Triglyceride Metabolic Process Immune Response Post-embryonic Development Gene Expression Gland Morphogenesis Cell Differentiation B Cell Differentiation Macrophage Differentiation Odontogenesis Of Dentin-containing Tooth CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Saliva Secretion Lymph Node Development Spleen Development Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Digestive Tract Development Post-embryonic Digestive Tract Morphogenesis Regulation Of Epithelial Cell Proliferation Leukocyte Migration
GWAS	Ankylosing spondylitis ( 23749187 ) Autoimmune thyroid disease ( 32581359 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Colorectal cancer ( 25990418 24737748 30529582 ) Colorectal cancer or advanced adenoma ( 30510241 ) Crohn's disease ( 17554300 17554261 28067908 25489960 22412388 21102463 18587394 ) Dental caries ( 23064961 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Hypothyroidism ( 27182965 ) Inflammatory bowel disease ( 28067908 23128233 ) Leukocyte telomere length ( 31171785 ) Mean corpuscular hemoglobin ( 27863252 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Red blood cell traits ( 23222517 ) Ulcerative colitis ( 28067908 20228799 20228798 )
Entrez ID	159296
HPRD ID	05992
Ensembl ID	ENSG00000119919
Uniprot IDs	Q8TAU0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	DNA-templated Transcription Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By Glucose DNA Binding Vascular Associated Smooth Muscle Cell Differentiation Trachea Cartilage Development Regulation Of Transcription By Glucose Negative Regulation Of Amyloid-beta Clearance Serum Response Element Binding Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Positive Regulation Of RNA Metabolic Process Primitive Streak Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Muscle Cell Myoblast Differentiation System Process Primary MiRNA Binding Positive Regulation Of DNA-templated Transcription Lung Smooth Muscle Development Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nervous System Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb General Adaptation Syndrome, Behavioral Process Transcription Factor TFIIA Complex Skin Morphogenesis Positive Thymic T Cell Selection Heart Trabecula Formation Positive T Cell Selection Eyelid Development In Camera-type Eye Neuron Projection Development Cardiac Myofibril Assembly Cardioblast Differentiation Long-term Synaptic Depression Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Filopodium Assembly Smooth Muscle Tissue Development Epithelial Cell-cell Adhesion Thymic T Cell Selection Morphogenesis Of An Epithelial Sheet