CST3

Name	cystatin C
Structure
Novel Interactors	1 novel interactors: POLE3
Interactors	9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Vesicle Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Defense Response Immune Response Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Tissue Remodeling Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization
Pathways	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Diseases	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS	Chronic kidney disease ( 20383146 ) Cystatin C levels ( 17903292 ) Glomerular filtration rate (cystatin C) ( 28452372 ) Plasma cystastin c levels in acute coronary syndrome ( 24952865 )
Entrez ID	1471
HPRD ID	05056
Ensembl ID	ENSG00000101439
Uniprot IDs	A0A0K0K1J1 P01034
PDB IDs	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
GO Terms Enriched among Interactors ?	Endolysosome Lumen Cysteine-type Endopeptidase Activity Proteoglycan Binding Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Extracellular Matrix Antigen Processing And Presentation Of Exogenous Antigen Tertiary Granule Lumen Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Lysosomal Lumen Antigen Processing And Presentation Extracellular Region Cysteine-type Peptidase Activity Extracellular Space Peptidase Activity Lysosome Fibronectin Binding Proteolysis Endopeptidase Inhibitor Activity Proteolysis Involved In Protein Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Maturation Cellular Response To Hormone Stimulus Macromolecule Metabolic Process Adult Locomotory Behavior Endopeptidase Activity Aspartic-type Peptidase Activity Enkephalin Processing Classical-complement-pathway C3/C5 Convertase Complex Activation Of Immune Response Melanosome Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Basement Membrane Disassembly Symbiont Entry Into Host Cell Peptidase Inhibitor Complex Insulin Catabolic Process Insulin Receptor Recycling Chromaffin Granule POZ Domain Binding